Sökning: "Grx1"

Visar resultat 1 - 5 av 20 avhandlingar innehållade ordet Grx1.

  1. 1. Cataract induced by UVR-B 300nm : characterization and genetic modulation of the lens sensitivity to oxidative stress

    Författare :Linda Maren Meyer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Lens; cataract; ultraviolet radiation; oxidative stress; Grx1; interleukins;

    Sammanfattning : Cataract is defined as an opacification of the lens resulting in visual impairment. Worldwide, it is the number one cause of blindness and there are currently no strategies to prevent the onset of the disease. Cataract surgery is the most commonly performed elective intervention in industrialized countries. LÄS MER

  3. 2. Prevention of Experimental Cataract Induced by UVR

    Författare :Martin Kronschläger; Per Söderberg; Madeleine Zetterberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cataract; ultraviolet radiation; apoptosis; thioltransferase; caffeine;

    Sammanfattning : Cataract is the leading cause of blindness in the world and is defined by opacification of the normally transparent lens of the eye. The major avoidable cause of cataract is ultraviolet radiation (UVR), but no current strategies have been developed to prevent the onset of cataract. LÄS MER

  4. 3. Cloning and characterization of human glutaredoxins

    Författare :Mathias Lundberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Reactive oxygen species, ROS, are generated in cells during aerobic metabolism. High and sustained levels of ROS pose a serious threat to all major cellular components, DNA, proteins mid lipids whereas controlled and physiological concentrations play a central role as a second messenger signal molecule involved in cell functions including, differentiation, proliferation, and apoptosis. LÄS MER

  5. 4. Biochemical properties of human glutaredoxins

    Författare :Catrine Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Glutaredoxins (Grxs) are highly conserved thiol-disulfide oxidoreductases that utilize electrons from the tripeptide glutathione (GSH) to catalyze thiol-disulfide exchange reactions. Bacteria, yeast and plants contain multiple dithiol Grxs, which are involved in different cellular processes like DNA synthesis, defense against oxidative stress, apoptosis, and regulation of transcription factor binding activity. LÄS MER

  7. 5. Cytotoxic mechanisms of selenium in cancer

    Författare :Eric Olm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Selenium is an essential trace element with a diverse number of functions in the body as part of multiple selenoproteins. Acknowledged for its cancer preventive properties in clinical trials, selenium has in recent years also evolved as a potential chemotherapeutic agent. LÄS MER