Sökning: "Growth hormone secretion pattern"

Visar resultat 1 - 5 av 15 avhandlingar innehållade orden Growth hormone secretion pattern.

  1. 1. Growth hormone and the heart in children

    Författare :Anders Nygren; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone secretion pattern; Cardiac dimensions; Growth hormone treatment;

    Sammanfattning : Background and Aims: The fact that growth hormone (GH) influences cardiovascular structure and function is well established through both human and animal studies. Despite being secreted in a pulsatile fashion, only the impact of peak GH concentrations on cardiac parameters has previously been reported, and the time-dependency of cardiovascular effects during GH treatment has not been detailed. LÄS MER

  3. 2. Growth hormone regulation of hepatic drug-metabolising enzymes in humans and rats

    Författare :Eva Rasmussen; Uppsala universitet; []
    Nyckelord :Medical sciences; growth hormone; IGF-I; somatostatin; cytochrome P450; regulation; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : There are pronounced sex-differences in the gene expression of several liver enzymes in the rat. The sex-differentiated secretion of growth hormone (GH) regulates these differences. We wanted to further investigate the mechanisms of this regulation in rats and to study the GH regulation of drug metabolism in man. LÄS MER

  4. 3. Growth hormone and PPARalpha in the regulation of genes involved in hepatic lipid metabolism

    Författare :Caroline Améen; Göteborgs universitet; []
    Nyckelord :Growth hormone; insulin; SREBP-1; lipogenic enzymes; microsomal triglyceride transfer protein; PPARalpha; LXRalpha; triglycerides; liver;

    Sammanfattning : Growth hormone (GH) plays a key role in the regulation of lipid and lipoprotein metabolism. Its sexually dimorphic secretory pattern regulates many sex-differentiated functions in the liver, such as triglyceride synthesis and VLDL secretion. LÄS MER

  5. 4. Molecular regulation of hormone secretion, growth and apoptosis of GLP-1-producing cells

    Författare :Camilla Kappe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Type 2 diabetes (T2D) spreads like an epidemic in today’s society, and there is a great need for new and improved treatments. T2D is characterized by hyperglycemia, resulting from impaired insulin production and insulin resistance in peripheral tissues. LÄS MER

  7. 5. Studies on growth hormone induced female-characteristic gene transcription in rat liver

    Författare :Cissi Gardmo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Growth hormone; liver; gene expression; sex differentiation; in vivo transfection; primary hepatocytes;

    Sammanfattning : Growth hormone (GH) secretion is sexually dimorphic, which has an impact on hepatic gene expression. This is particularly pronounced in rats but has also been demonstrated in other species, including humans. LÄS MER