Sökning: "Graves’ ophthalmopathy"

Hittade 4 avhandlingar innehållade orden Graves’ ophthalmopathy.

  1. 1. Molecular Etiology of Graves’ Disease and Associated Ophthalmopathy

    Författare :Tereza Planck; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; association study; Graves’ disease; Graves’ ophthalmopathy; immediate early genes; inflammation; adipogenesis; thyrostimulin; BTG2; CYR61; COX2; ZFP36; gene expression; SCD; SNP;

    Sammanfattning : Graves' disease (GD) is a complex autoimmune disorder characterized by hyperthyroidism and diffuse goitre. 25-50% of the patients with GD develop eye symptoms, Graves' ophthalmopathy (GO). The overall aim of this thesis was to explore the molecular etiology of GD and GO. LÄS MER

  3. 2. Molecular Mechanisms of Graves' Ophthalmopathy. A focus on smoking and radioiodine

    Författare :Bushra Shahida; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Graves’ disease. Graves’ ophthalmopathy; radioiodine; inflammation; adipogenesis; IL-1ß; IL-6; PTGS2 COX2; PGE2; CTLA-4; B lymphocytes; T lymphocytes; Simvastatin; Diclofenac; SNP; gene expression; IGF-1;

    Sammanfattning : Graves’ disease (GD) is an autoimmune disease characterized by hyperthyroidism and is caused by an interplayof genetic and environmental factors. One-third of patients with GD develop Graves’ ophthalmopathy (GO). Keyprocesses in the pathogenesis of GO are inflammation and adipogenesis in orbital tissue. LÄS MER

  4. 3. Thyroid associated ophthalmopathy : treatment for hyperhyroidism and evaluation of methods for measuring saccadic eye movements

    Författare :Frank Träisk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Graves disease; thyroid associated ophthalmopathy; saccade; main sequence; magnetic scleral search coil; infrared reflection; radioiodine; anti-thyroid drugs; smoking;

    Sammanfattning : Thyroid associated ophthalmopathy (TAO) is the orbital manifestation of autoimmune thyroid disease that clinically affects about 30-50 % of patients with Graves disease (GD). The clinical features of TAO are in most patients mild and transient. LÄS MER

  5. 4. Presence of extrathyroidal TSH-receptor, with special reference to its role in neonatal regulation of lipolysis

    Författare :Annika Janson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :adaptation; adipocytes; Graves disease; growth hormone; human; hyper thyroidism; infant; insulin; metabolism; TSHR stimulating antibodies; thyrotropin; TSH.;

    Sammanfattning : At birth, the newborn child must utilize stored energy until lactation is established. The main source of energy is fat - that is, triglycerides stored in the white adipose tissue. This study deals with hormonal regulation of lipolysis in the neonatal period. LÄS MER