Sökning: "Gram-negative bacteria"

Visar resultat 21 - 25 av 226 avhandlingar innehållade orden Gram-negative bacteria.

  1. 21. Pharmacokinetic and Pharmacodynamic Modeling of Antibiotics and Bacterial Drug Resistance

    Författare :Ami Fazlin Syed Mohamed; Lena Friberg; Teresa Dalla Costa; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacometrics; pharmacokinetics; pharmacodynamics; modeling; antibiotics; resistance; combination; Gram-negative bacteria; gentamicin; colistin; meropenem; newborn infants; critically ill patients; Infectious Diseases; Infektionssjukdomar; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : Exposure to antibiotics is an important factor influencing the development of bacterial resistance.  In an era where very few new antibiotics are being developed, a strategy for the development of optimal dosing regimen and combination treatment that reduces the rate of resistance development and overcome existing resistance is of utmost importance. LÄS MER

  3. 22. Design and synthesis of KDO-derivatives as inhibitors of lipopolysaccharide biosynthesis in Gram-negative bacteria : a new class of antibacterial agents

    Författare :Anita M. Jansson; Stockholms universitet; []
    Nyckelord :;

    Sammanfattning : .... LÄS MER

  4. 23. Novel approaches to mucosal vaccine development Strategies in vaccine antigen production, construction of a novel mucosal adjuvant and studies of its mode of action

    Författare :Manuela Terrinoni; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vaccine development; plasmid maintenance; Gram-negative bacteria; ; essential genes; complementation; Cholera Toxin; adjuvanticity; NF-kB; mmCT; Gram-negative bacteria;

    Sammanfattning : Although most infections begin at a mucosal surface and may be prevented by effective vaccine stimulation of the local mucosal immune system, there are so far only a few mucosal vaccines available for human use. This thesis spans several areas that are important for future development of mucosal vaccines. LÄS MER

  5. 24. Assembly and adhesive properties of curli : a stationary phase-specific surface organelle in Gram-negative enteric bacteria

    Författare :Mårten Hammar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Escherichia colilcurli fimbriae csgstarvation;

    Sammanfattning : The natural environments of bacteria are most often characterized by suboptimal conditions for growth, e. g., limited supply of nutrients. Consequently, periods of dormancy or negligible growth are the rule rather than the exception. LÄS MER

  7. 25. On the development of low level resistance in gram-positive and gram-negative bacteria after antibiotic exposure

    Författare :Gunilla Rådberg; Signe Ringertz; Östergötlands Läns Landsting; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Resistance has been found to develop and spread via several mechanisms against virtually all clinically available antimicrobial agents. Increasing use of antibiotics has been shown to correlate to increasing incidence of bacterial resistance. LÄS MER