Sökning: "Gram-negative bacteria"

Visar resultat 16 - 20 av 226 avhandlingar innehållade orden Gram-negative bacteria.

  1. 16. Molecular basis for trimethoprim and sulphonamide resistance in Gram negative pathogens

    Författare :Malin Grape; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Resistance to antibiotics is becoming an important global public health problem. Infectious diseases are still among the major causes of disease and death in many parts of the world and the possibilities to treat bacterial infections are now threatened due to the spread of antibiotic resistance. LÄS MER

  3. 17. Novel actions of thrombin-derived host defense peptides

    Författare :Finja Hansen; Lund Dermatologi och venereologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Host defense peptides; Thrombin; Monocytes Macrophages; Gram-negative bacteria; LPS; TLR; Phagocytosis; Inflammation; Endocytosis;

    Sammanfattning : Thrombin-derived C-terminal peptides (TCPs) constitute a novel class of immunomodulatory host defense peptides, generated during infection and inflammation. Previous investigations have shown that TCPs of 2-3 kDa inhibit pro-inflammatory immune responses in vitro and in vivo, but their mode of action remained unclear. LÄS MER

  4. 18. Immunity to Salmonella infection

    Författare :Cecilia Johansson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; cytokines; antigen presentation; liver; dendritic cells; Salmonella; gram negative bacteria;

    Sammanfattning : The immune system has several strategies to combat infections. The present study investigates various aspects of the interaction between Gram negative bacteria, particularly Salmonella, and antigen presenting cells (APC). Salmonella is an intracellular bacterium infecting mice and man. LÄS MER

  5. 19. Chromosomal β-lactamases in enterobacteria and in vivo evolution of β-lactam resistance

    Författare :Sven Bergström; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram negative bacteria; ß-lactamase genes; divergence of neighbouring cperons; ß-lactamase hyperproduction; evolution of control sequences;

    Sammanfattning : The ß-lactam antibiotics are the most important antibacterial agents in the treatment of infectious diseases. A severe problem in ß-lactam therapy is the emergence of ß-lactam resistant bacteria. Clinical ß-lactam resistance is most often due to the production of ß-lactamases. ß-lactamase genes reside either on plasmids or on the chromosome. LÄS MER

  7. 20. β-lactam combinations against multidrug-resistant Enterobacterales : Exploring combination effects and resistance development

    Författare :Lisa Allander; Thomas Tängdén; Linus Sandegren; Pernilla Lagerbäck; Arnfinn Sundsfjord; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram-negative bacteria; antibiotic combination therapy; antibiotic resistance; beta-lactams; beta-lactamase inhibitors; Infektionssjukdomar; Infectious Diseases;

    Sammanfattning : The β-lactam antibiotics are a cornerstone in treating bacterial infections, but the increasing prevalence of antibiotic resistance worldwide threatens their effectiveness. The main driver of β-lactam resistance is the production of β-lactamases, which are bacterial enzymes that inactivate the antibiotic. LÄS MER