Sökning: "Glycomimetic"

Hittade 5 avhandlingar innehållade ordet Glycomimetic.

  1. 1. Synthetic Galectin Inhibitors Selective O-galactosyl aldoximes, multivalent lactosides and galactose-mimicking mannosides

    Författare :Johan Tejler; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Proteiner; enzymology; Proteins; Glycomimetic; Fragment based; Cluster effect; Multivalence; Triazole; Inhibitor; Aldoxime; enzymologi; Organic chemistry; Organisk kemi; Galectin; Lectin;

    Sammanfattning : This thesis describes the design, synthesis and evaluation of synthetic inhibitors for the carbohydrate binding proteins called galectins. Potent and selective inhibitors can be used as important research tools in the endeavor to chart the true role of galectins in biological events such as cancer and inflammation and possibly as lead for future galectin targeting drugs. LÄS MER

  3. 2. Novel glycomimetic inhibitors and proteolysis-targeting chimeras for human galectins

    Författare :Mujtaba Hassan; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Galectins; Galectin-3; Galectin-8; benzimidazole; affinity; selectivity; X-ray; PROTAC;

    Sammanfattning : Galectins are a family of soluble proteins that bind β-D-galactopyranoside-containing glycoconjugates through their conserved carbohydrate-recognition domains. Galectins have emerged as promising drug targets due to their involvement in various pathological conditions, such as tumor growth and metastasis, autoimmune and inflammatory diseases, as well as metabolic disorders. LÄS MER

  4. 3. Design and Synthesis of Glycomimetics as Selective Galectin Inhibitors

    Författare :Mukul Mahanti; Centrum för analys och syntes; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Galectin; Galectin inhibitors; Glycomimentics; Epimeric switch; MD simulation;

    Sammanfattning : In last couple of decades the field of glycobiology has developed rapidly due to the increased understanding of glycans’ abilities to encode biological information, which may have impact on biological event and disease, such as for example tumour growth and inflammation. This development has been accompanied by an increasing focus on drug discovery revolving around a category of carbohydrate-based drugs termed glycomimetics. LÄS MER

  5. 4. The sweet side of molecular structure : NMR spectroscopic studies of glycans and their interactions with proteins

    Författare :Christoffer Hamark; Göran Widmalm; Mario Schubert; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioorganic chemistry; glycans; ligand-based NMR; molecular simulations; protein-carbohydrate interactions; lectins; carbohydrate conformations; 77Se NMR; structure-reactivity relationships; super-armed donors; organisk kemi; Organic Chemistry;

    Sammanfattning : In this thesis, within the topic of bioorganic chemistry, the molecular structure of carbohydrates has been studied. Carbohydrates, or glycans, are ubiquitous biomolecules exhibiting a wide range of biological roles. LÄS MER

  7. 5. Development and Evaluation of Tools to Explore Posttranslational HexNAc-Tyrosine and Mucin-Type O-Glycosylation

    Författare :Sandra Behren; Ulrika Westerlind; Mikael Elofsson; Carmen Galan; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glycopeptides; mucins; mucin type-O-glycosylation; microarrays; tyrosine-O-HexNAcylation; lectins; MUC1 cancer vaccines; TcdA; LecB; galectins; LacdiNAc; antibodies; biologisk kemi; biological chemistry; Biorganic Chemistry; bioorganisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : Glycosylation is the most abundant form of post-translational modification (PTM). Recently, O-glycosylation attracted much attention in the glycoproteomic field due to its association with various diseases, such as pathogenic infections and cancer. LÄS MER