Sökning: "Glycogen Synthase Kinase"

Visar resultat 6 - 10 av 21 avhandlingar innehållade orden Glycogen Synthase Kinase.

  1. 6. Molecular consequences of cellular UDP-glucose deficiency

    Författare :Juan Carlos Higuita V; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A Chinese hamster fibroblast mutant cell line, deficient in UDP-glucose (UDPG), denoted as Qc, and its counterpart cell line with normalized levels of UDPG (G3), were used to determine some molecular consequences of chronic UDPG deficiency. The UDPG deficient cells lacked glycogen, had elevated rates of glucose uptake and a decreased capacity to synthesize glycogen after 120h of culture. LÄS MER

  3. 7. Mechanisms of Sensitization to Apoptosis in Multiple Myeloma

    Författare :Anna Hammarberg; Helena Jernberg Wiklund; Kenneth Nilsson; Federico Caligaris-Cappio; Uppsala universitet; []
    Nyckelord :Pathology; multiple myeloma; apoptosis; IGF-1; mTOR; IAP; GSK3; rapamycin; PPP; dexamethasone; CT99021; Patologi;

    Sammanfattning : Multiple myeloma (MM) is a hematological tumor of plasma blast/plasma cell origin heterogeneous with respect to the morphological differentiation stage of the tumor cells, genetic alterations and course of disease. A challenge in MM research is to overcome resistance to therapy, which inevitably arises. LÄS MER

  4. 8. Protein phosphatases and kinases implicated in Alzheimer's disease abnormal tau phosporylation

    Författare :Jin-jing Pei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : This thesis describes the distribution, levels and activities of a number of protein kinases and protein phosphatases (PPs) implicated in the abnormal phosphorylation of the tau protein that forms the paired helical filaments (PHFs) of Alzheimer's disease (AD) neurofibrillary tangles (NFTs). Paper I describes the immunocytochemical localization of PP-1, PP-2A, PP-2B and PTP-1B, as well as the protein kinase MAP kinase and p34cdc2 in the hippocampal formation of AD and control brains. LÄS MER

  5. 9. Regulation of glucose transport and insulin-stimulated GLUT4 translocation in skeletal muscle

    Författare :Jorge E Rincón Viatela; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :skeletal muscle; glucose transport; insulin resistance; hyperglycaemia; steroid hormones; smoking; nicotine;

    Sammanfattning : Skeletal muscle represents about 40% of body mass and accounts for at least 80% of glucose disposal under insulin-stimulated conditions. Furthermore, GLUT4 transport protein is the primary component of the glucose transport system in skeletal muscle. LÄS MER

  7. 10. The impact of glucotoxicity on pancreatic β-cell function

    Författare :Sarheed Jabar Muhammed; Islet cell physiology; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cAMP PKA system; iNOS; Type 2 diabetes; GSIS; PDE; GK rat; ZDF fa fa rat; GPR40; VDAC1; VDAC2; GSK-3β; ChREBP; TXNIP; resveratrol.;

    Sammanfattning : Type 2 diabetes mellitus is connected with elevated plasma glucose levels which negatively influence β-cells and cause impaired glucose-stimulated insulin secretion (GSIS). The aim of present thesis was to investigate the impact of long-term hyperglycemia on the pancreatic islet β-cell function. LÄS MER