Sökning: "Glycogen Synthase Kinase"

Visar resultat 16 - 20 av 21 avhandlingar innehållade orden Glycogen Synthase Kinase.

  1. 16. PTEN and Akt signalling in Alzheimer’s disease

    Författare :Annika Rickle; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PTEN; Akt; GSK3beta; post-mortem brain; rat primary cortical neurons;

    Sammanfattning : Akt / protein kinase B is an important cell survival kinase that modulates the activity of a range of pro-apoptotic proteins. A major downstream target of Akt is glycogen synthase kinase-3beta (GSK3beta) that phosphorylates the microtubule-associated protein tau. LÄS MER

  3. 17. Apolipoprotein E and Alzheimer's diseases : signals and effects

    Författare :Ángel Cedazo-Minguez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's Disease (AD) is the most frequent cause of dementia in the elderly. A diagnosis of AD is confirmed post-mortem by the accumulation of neuritic plaques (NP) and neurofibrillary tangles (NFTs) in brain tissue. LÄS MER

  4. 18. Functional and metabolic alterations in skeletal muscle in response to physiological and pathophysiological stressors

    Författare :Theresa Mader; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Skeletal muscle performance is essential for our body’s movement as well as for the wholebody metabolism. In health and disease, skeletal muscle is exposed to various endogenous and exogenous stressors, influencing its physiological functions. LÄS MER

  5. 19. Endocrine signaling and molecular aberrations in primary hyperparathyroidism

    Författare :Felix Haglund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Primary hyperparathyroidism is a common endocrine disorder, characterized by an inappropriate increase in serum parathyroid hormone (PTH) levels. It is most often caused by a single benign parathyroid tumor. LÄS MER

  7. 20. Wnt signalling in the development of ventral midbrain dopaminergic neurons

    Författare :Gonçalo de Sá e Sousa de Castelo-Branco; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dopaminergic Neuron; Ventral Midbrain Development; Writs; Dickkopf; beta-catenin; GSK-3beta; Stem Cells; Neural Precursors;

    Sammanfattning : Dopaminergic (DA) neurons in the ventral midbrain (VM) are one of the major cell types lost in Parkinson's disease (PD). Proof-of-principle exists for cell replacement therapies for PD, but wider application is halted by the unavailability of abundant sources of DA neurons. Stem cells might constitute one of these sources. LÄS MER