Sökning: "Glycogen Storage Disease"
Hittade 5 avhandlingar innehållade orden Glycogen Storage Disease.
1. Human glycogen synthase genes. Role in insulin resistance and hypoglycaemia
Sammanfattning : Effective insulin-stimulated storage of excess glucose after a meal, and its rapid mobilisation in the fasting state provide basis of glucose homeostasis. Glycogen is the macromolecular storage form of glucose and glycogen synthase (GS) is the rate-limiting enzyme in glycogen synthesis. Skeletal muscle and liver are the major depots of glycogen. LÄS MER
2. Two new disorders of glycogen metabolism
Sammanfattning : Glycogen is a polymer of glucose and serves as a source of rapidly available energy. Glycogen synthesis is initiated by autoglucosylation of glycogenin. Two glycogenin genes, GYG1 and GYG2, encode the two isoforms glycogenin-1 and -2, respectively. LÄS MER
3. Crisis in Energy Metabolism - Mitochondrial Defects and a New Disease Entity
Sammanfattning : Impairment of energy metabolism may be associated with severe implications for affected individuals since all fundamental cell functions are energy-dependent. Disorders of energy metabolism are often genetic and associated with defects in the oxidative phosphorylation in mitochondria. LÄS MER
4. Pathways controlling metabolic and hypertrophic responses in skeletal muscle
Sammanfattning : Skeletal muscle displays an extensive capacity to adapt to a wide range of metabolic and mechanical stressors. As an insulin-sensitive and exercise-responding tissue, it plays a key role in the context of therapeutic interventions targeting metabolic diseases including type 2 diabetes (T2D) and obesity. LÄS MER
5. Functional and metabolic alterations in skeletal muscle in response to physiological and pathophysiological stressors
Sammanfattning : Skeletal muscle performance is essential for our body’s movement as well as for the wholebody metabolism. In health and disease, skeletal muscle is exposed to various endogenous and exogenous stressors, influencing its physiological functions. LÄS MER