Sökning: "Glycoconjugates"

Visar resultat 1 - 5 av 34 avhandlingar innehållade ordet Glycoconjugates.

  1. 1. Glycoconjugates : synthesis and investigation of carbohydrate-protein interactions

    Författare :Sara Spjut; Mikael Elofsson; Ulf Ellervik; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugates; Carbohydrates; Galactose; Glucose; Solid-phase synthesis; SPOS; Glycosylation; Gel-phase 19F NMR spectroscopy; Fluorinated linker; Carbohydrate array; Microtiter plates; Carbohydrate-protein interactions; carbamate linker; Fsec; Protecting group; Fluorinated protecting group; Multivalent glycoconjugates; Adenovirus; Ad37; Epidemic keratoconjunctivitis; EKC; Sialic acid; Adenovirus inhibitor; Trivalent; Tetravalent; X-ray crystal structure; Bioorganic chemistry; Bioorganisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : To study the functions of glycoconjugates in biological systems reliable and efficient protocols for glycoconjugate synthesis are needed. To reach this goal we have developed methods for solid-phase synthesis of glycoconjugates that can be monitored with gel-phase 19F spectroscopy using fluorinated linkers, building blocks, and protecting groups. LÄS MER

  3. 2. Glycoconjugates : Solid-phase synthesis and biological applications

    Författare :Fredrik Wallner; Mikael Elofsson; Jan Kihlberg; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugate; Glycolipid; Solid-phase synthesis; Glycosylation; Gel-phase 19F-NMR spectroscopy; Fluorinated linker; Carbohydrat array; CD1; Organic chemistry; Organisk kemi;

    Sammanfattning : Glycoconjugates are biologically important molecules with diverse functions. They consist of carbohydrates of varying size and complexity, attached to a non-sugar moiety as a lipid or a protein. Glycoconjugate structures are often very complex and their intricate biosynthetic pathways makes overexpression difficult. LÄS MER

  4. 3. Carbohydrate-Based Inhibitors of Pathogen Adhesion to Cell Surface Glycoconjugates

    Författare :Henrik C Hansen; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Galabiose analogs; Globotriose analogs; Escherichia coli; verotoxin; PapG adhesion; Streptococcus suis; Dendrimers; Multivalency; Amino-deoxy analogs; Organic chemistry; Inhibitor; Ceramide analogs; Glycoconjugates; Organisk kemi;

    Sammanfattning : The fact that a growing number of pathogens develop resistance against traditional treatment is a growing medical problem. Infections, which until now have been harmless, might turn into life threatening diseases. These problems have led to an intensified search for alternative treatments. Analogs of cell surface glycoconjugates are an alternative. LÄS MER

  5. 4. Conformational, dynamics and interaction studies of glycoconjugates by NMR spectroscopy

    Författare :Kristina Lycknert; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Glycoconjugates; Magnetic resonance spectroscopy;

    Sammanfattning : .... LÄS MER

  7. 5. Design and Synthesis of Sialic Acid Conjugates as Inhibitors of EKC-causing Adenoviruses

    Författare :Susanne Johansson; Jan Kihlberg; Mikael Elofsson; Stefan Oscarson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Sialic acid; sialylmimetics; sialylation; multivalency; glycoconjugates; adenovirus; antiviral agents; epidemic keratoconjunctivitis; Bioorganic chemistry; Bioorganisk kemi;

    Sammanfattning : The combat against viral diseases has been, and still is, a major challenge in the field of drug development. Viruses are intracellular parasites that use the host cell ma-chinery for their replication and release. Therefore it is difficult to target and destroy the viral particle without disturbing the essential functions of the host cell. LÄS MER