Sökning: "Glutamate release"

Visar resultat 21 - 25 av 90 avhandlingar innehållade orden Glutamate release.

  1. 21. Neuropeptide release in the rat dorsal horn in models of persistent pain : effects of opioids

    Författare :Abdullahi Warsame Afrah; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Axotomy; Inflammation; Long term potentiation; Capsaicin; Opioids; Cholecystokinin; Substance P; Glutamate; NMDA; Spinal cord; Microdialysis; Radioimmunoassay.;

    Sammanfattning : Nerve injury and tissue inflammation may lead to exaggerated responses to both noxious stimuli (hyperalgesia) and innocuous stimuli (allodynia). Altered release pattems of neurotransmitters in the dorsal hom of the spinal cord have been suggested to contribute to hyperalgesia and allodynia. LÄS MER

  3. 22. Physiopathological aspects of NMDA transmission in the basal ganglia : in vitro and in vivo release studies

    Författare :Michele Morari; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :basal ganglia; NMDA; dizocilpine; microdialysis; slices; synaptosomes; dopamine; acetylcholine; glutamate; GABA; 6OH-dopamine;

    Sammanfattning : N-methyl-D-aspartic acid (NMDA) is an excitatory amino acid selectively acting on a subclass of glutamate receptors (the NMDA ionotropic receptor) which has been involved in many of the physiological and pathological effects of glutamate in the CNS. The basal ganglia are particularly enriched in NMDA receptors and NMDA receptor activation in the basal ganglia has been involved in the expression of motor behaviour. LÄS MER

  4. 23. On the role of metabotropic glutamate receptors in motor control : analysis of synaptic, cellular and network properties

    Författare :Patrik Krieger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :calcium channels; lamprey; locomotion; metabotropic glutamate receptors; neuronal network; spinal cord; synaptic transmission;

    Sammanfattning : The organization of neurons into neuronal networks is a basic feature of the central nervous system. An understanding of the function of neuronal networks requires knowledge on both synaptic connectivity and cellular properties. LÄS MER

  5. 24. Endotoxin-, glutamate- and drug-induced inflammation and cytotoxicity with emphasis on signal transduction mechanisms

    Författare :Ylva Edling; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inflammatory cells such as monocytes and glial cells play an important role in the pathogenesis of ischemic- or drug-induced brain or liver injury. Excessive concentrations of glutamate is toxic to neural cells, and triggers a series of transcriptional events beginning with the expression of the immediate early genes like c-fos and c-jun, which in turn affect the expression of other genes necessary for the development of brain injury. LÄS MER

  7. 25. Metabolic intervention with amino acids in coronary surgery : A clinical study with special reference to effects of glutamate and aspartate on myocardial metabolism

    Författare :Ingemar Vanhanen; Folke Nilsson; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Amino acids, particularly glutamate and aspartate, have been suggested to be important for the tolerance to myocardial ischemia and for the recovery of the oxidative metabolism of the heart after ischemia. The objective of the present work was to investigate myocardial metabolism and how it is influenced by intravenous supply of glutamate and aspartate in association with coronary artery bypass grafting (CABG). LÄS MER