Sökning: "Glucose metabolism disorders"

Visar resultat 1 - 5 av 40 avhandlingar innehållade orden Glucose metabolism disorders.

  1. 1. Two new disorders of glycogen metabolism

    Författare :Johanna Nilsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glycogen; Glycogenin; Glycogenosis; Glycogen storage disease; Glycosylation; Mass spectrometry;

    Sammanfattning : Glycogen is a polymer of glucose and serves as a source of rapidly available energy. Glycogen synthesis is initiated by autoglucosylation of glycogenin. Two glycogenin genes, GYG1 and GYG2, encode the two isoforms glycogenin-1 and -2, respectively. LÄS MER

  3. 2. Role of nuclear receptors in the regulation of human adipose tissue metabolism

    Författare :Prasad G. Kamble; Jan W Eriksson; Ingrid Dahlman; Uppsala universitet; []
    Nyckelord :human adipose tissue; nuclear receptors; glucocorticoids; estrogen; PPARγ; lipocalin 2; glucose uptake; lipolysis; adipogenesis; genotype-based recall;

    Sammanfattning : Nuclear receptors modulate expression of genes involved in adipose tissue (AT) metabolism. Their improved understanding may provide new treatment options for metabolic disorders such as obesity, insulin resistance (IR) and type 2 diabetes (T2D). LÄS MER

  4. 3. Effects of immunosuppressive drugs on human adipose tissue metabolism

    Författare :Maria J Pereira; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cyclosporin A; tacrolimus; rapamycin; glucocorticoids; new onset diabetes after transplantation; adipocytes; insulin signalling; glucose uptake; lipolysis; lipogenesis;

    Sammanfattning : The immunosuppressive agents (IAs) rapamycin, cyclosporin A and tacrolimus, as well as glucocorticoids are used to prevent rejection of transplanted organs and to treat autoimmune disorders. Despite their desired action on the immune system, these agents have serious long-term metabolic side-effects, including dyslipidemia and new onset diabetes mellitus after transplantation. LÄS MER

  5. 4. Mathematical Modelling of Cerebral Metabolism : From Ion Channels to Metabolic Fluxes

    Författare :Nicolas Sundqvist; Gunnar Cedersund; Maria Engström; Roland Nilsson; Sebastian Sten; João Duarte; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The brain is the most metabolically active organ in the human body and therefore rely on a continuous supply of oxygen and glucose. Neuronal stimulation in specific regions of the leads to the firing of action potentials, a process facilitated by voltage-gated ion channels in the neurons’ cell membranes. LÄS MER

  7. 5. Metabolic Disturbances in Relation to Serum Calcium and Primary Hyperparathyroidism

    Författare :Emil Hagström; Per Hellman; Ewa Lundgren; Jonas Rastad; Svante Jansson; Uppsala universitet; []
    Nyckelord :Surgery; Primary hyperparathyroidism; Parathyroidectomy; Insulin sensitivity; Lipoproteins; Glucose metabolism disorders; Bone density; Calcium; Kirurgi;

    Sammanfattning : Primary hyperparathyroidism (pHPT), characterized by elevated serum levels of calcium and parathyroid hormone (PTH), is associated with a number of metabolic derangements causing secondary manifestations. These include osteoporosis and increased risk of fractures, but also risk factors for cardiovascular morbidity and mortality. LÄS MER