Sökning: "Glucose level"

Visar resultat 1 - 5 av 314 avhandlingar innehållade orden Glucose level.

  1. 1. Glucose and lipid metabolism in insulin resistance : an experimental study in fat cells

    Författare :Jonas Burén; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Public health; adipocyte; insulin resistance; type 2 diabetes; insulin signalling; glucose uptake; insulin; glucose; dexamethasone; insulin receptor substrate; protein kinase B; GLUT4; lipoprotein lipase; Folkhälsomedicin; Public health medicine research areas; Folkhälsomedicinska forskningsområden; medicin; Medicine;

    Sammanfattning : Type 2 diabetes is usually caused by a combination of pancreatic β-cell failure and insulin resistance in target tissues like liver, muscle and fat. Insulin resistance is characterised by an impaired effect of insulin to reduce hepatic glucose production and to promote glucose uptake in peripheral tissues. LÄS MER

  2. 2. Oxidative stress and inflammation as a response to glucose exposure and dialysis

    Författare :Anna Bryland; Njurmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glucose; glucose degradation products; dialysis; diabetes; oxidative stress; inflammation; endothelial dysfunction;

    Sammanfattning : Abstract: The main player of this thesis is glucose, both on a cellular level and with a clinical approach. Too much or wrongly handled glucose contributes to increased inflammation and oxidative stress, which is reinforced by the negative influences of uraemia and dialysis treatment. LÄS MER

  3. 3. Glucose- and hypoxia-regulated insulin gene expression

    Författare :Linda Tillmar; Jens Höiriis Nielsen; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; islet; beta-cell; insulin; mRNA stability; PTB; glucose; hypoxia; mTOR; p70s6k; ceramide; redox; ROS; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

    Sammanfattning : Although extensively studied, there are still many unanswered questions regarding the exact regulation of insulin gene expression. This is important to further investigate since it will hopefully help us understand the pathophysiology of some types of diabetes. LÄS MER

  4. 4. Plant UDP-glucose Pyrophosphorylase : Function and Regulation

    Författare :Meng Meng; Leszek Kleczkowski; Javier Pozueta-Romero; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; UDP-glucose pyrophosphorylase; carbohydrate metabolism; in vivo regulation; T-DNA knockout; heterologous expression; isozyme; mutagenesis; kinetic property; oligomerization; Plant physiology; Växtfysiologi;

    Sammanfattning : UDP-glucose pyrophosphorylase (UGPase) is an important enzyme of carbohydrate metabolism in all living organisms. The main aim of this thesis was to investigate the function and regulation of plant UGP genes as well as the UGPase proteins. LÄS MER

  5. 5. Fat cell insulin resistance : an experimental study focusing on molecular mechanisms in type 2 diabetes

    Författare :Frida Renström; Jan Eriksson; Anna Krook; Umeå universitet; []
    Nyckelord :AGRICULTURAL SCIENCES; LANTBRUKSVETENSKAPER; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; adipocyte; insulin signaling; insulin; glucose; IRS-1; glucose uptake; insulin resistance; typ 2 diabetes; serum; Medicine; Medicin;

    Sammanfattning : The aim of the present thesis was to further increase our understanding of mechanisms contributing to and maintaining cellular insulin resistance in type 2 diabetes (T2D). For this reason, the effects of high glucose and insulin levels on glucose transport capacity and insulin signaling, with emphasis on insulin receptor substrate 1 (IRS-1) were assessed in fat cells. LÄS MER