Sökning: "Glial cells"
Visar resultat 1 - 5 av 256 avhandlingar innehållade orden Glial cells.
1. The role of glial cells in alpha-synuclein pathology : Focus on degradation, cell-to-cell propagation and inflammation
Sammanfattning : Growing evidence emphasizes the role of astrocytes and microglia in Parkinson’s disease (PD) and Alzheimer’s disease (AD). Yet, little is known about their impact on specific disease processes and if their involvement is beneficial or detrimental. LÄS MER
2. Neuronal and glial differentiation of expanded neural stem and progenitor cells; in vitro and after transplantation
Sammanfattning : In this thesis we have used cells dissected from the lateral ganglionic eminence (LGE), the medial ganglionic eminence (MGE), and the cortical primordium of the embryonic mouse forebrain. The tissue was dissected from either i) wild-type mice, ii) green fluorescent protein (GFP)-, or iii) Gtv-a-expressing transgenic mice, and subsequently grown and expanded in vitro using two different protocols. LÄS MER
3. Ion Transport in Glial and Neuroblastoma Cells
Sammanfattning : The aim of this thesis has been to increase our understanding of the ion channel function and the ion transport mechanisms in glial cells. The analysis has also covered Na channel function in human neuroblastoma cells in order to get a basis for similar studies of glial cells In paper I isotopes 42K and 201 Tl were used to compare the K+ transport properties in cell lines from human malignant gliomas (U-251MG and Tp-378MG), carcinomas, and brain metastasis. LÄS MER
4. Neural Stem and Progenitor Cells as a Tool for Tissue Regeneration
Sammanfattning : Neural stem and progenitor cells (NSPC) can differentiate to neurons and glial cells. NSPC are easily propagated in vitro and are therefore an attractive tool for tissue regeneration. Traumatic brain injury (TBI) is a common cause for death and disabilities. A fundamental problem following TBI is tissue loss. LÄS MER
5. Neuroprotection in the Injured Spinal Cord : Novel Strategies using Immunomodulation, Stem cell Transplantation and Hyaluronic acid Hydrogel carriers
Sammanfattning : The overall aim of this thesis was to establish strategies to minimize secondary damage to the injured spinal cord. Secondary damage that follows spinal cord injury (SCI) involves inflammatory and excitotoxic pathways. LÄS MER