Sökning: "Genotype"

Visar resultat 21 - 25 av 697 avhandlingar innehållade ordet Genotype.

  1. 21. Microenvironmental Impact on Tumour Cell Phenotype and Genotype in Adult and Paediatric Tumours

    Författare :Hiroaki Yasui; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer genotype; cancer phenotype; malignant rhabdoid tumour; neuroblastoma; ovarian cancer; tumour evolution; Wilms tumour;

    Sammanfattning : This thesis explores how the tumour microenvironment affects the phenotype and shapes the evolution of cancer cells. It encompasses four separate studies:First, we explored the effect of chemokines on the peritotumoral microenvironment of ovarian cancer. LÄS MER

  3. 22. Genotype/ phenotype correlation of two neuropsychiatric diseases. A genetic study of CDG1a and Rett syndrome

    Författare :Anna Erlandson; Göteborgs universitet; []
    Nyckelord :CDG 1a; PMM2; Rett syndrome; MECP2; mutations; genotype phenotype; DHPLC; MLPA;

    Sammanfattning : The aim of this thesis was to investigate the effects of mutations in the genes that cause the two neuropsychiatric diseases congenital disorder of glycosylation (CDG) type Ia and Rett syndrome. These two diseases affect children's central and peripheral nervous systems, causing mental retardation and neuronal impairment. LÄS MER

  4. 23. Exotoxins of Aggregatibacter actinomycetemcomitans and periodontal attachment loss in adolescents

    Författare :Carola Höglund Åberg; Anders Johansson; Rolf Claesson; Dorte Haubek; Andrea Mombelli; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Aggregatibacter actinomycetemcomitans; periodontal attachment loss; JP2 genotype; non-JP2 genotype; LtxA; Cdt; Infectious Diseases; infektionssjukdomar;

    Sammanfattning : Aggregatibacter actinomycetemcomitans is an oral bacterium that is mainly associated with aggressive forms of periodontitis, which most often starts at an early age. Amongst the virulence factors of A. LÄS MER

  5. 24. Genotype-phenotype studies in brain tumors

    Författare :Soma Ghasimi; Ulrika Andersson; Beatrice Melin; Roger Henriksson; Clemens Dirven; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glioma; Meningioma; SNP; IHC; FISH; LRIG2; EGF; EGFR; ERBB2; ER; CDKN2A B; IDH1; onkologi; Oncology;

    Sammanfattning : Meningioma and glioma are the most common primary brain tumors, but their etiologies are largely unknown. Although meningioma is usually benign, their intracranial location can lead to lethal consequences, and despite progress in surgery, radiotherapy, and chemotherapy the prognosis for patients with glioma remains poor. LÄS MER

  7. 25. Spatial and temporal ecology of oak-associated fungal communities

    Författare :Maria Faticov; Ayco Tack; Peter Hambäck; Paula Baptista; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; abiotic and biotic forces; climate warming; community ecology; foliar fungal community; host genotype; plant microbiome; powdery mildew; seasonal dynamics; warming-by-genotype interaction; Quercus robur; soil fungal community; spatial patterns; ekologi och evolution; Ecology and Evolution;

    Sammanfattning : Plants host a large diversity of microorganisms, which includes fungi, bacteria and archaea. Among these, fungi are highly diverse, and known to play a vital role in plant health and in regulation of the essential ecosystem functions. LÄS MER