Sökning: "Genotype imputation"
Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Genotype imputation.
1. Methodology and Infrastructure for Statistical Computing in Genomics : Applications for Ancient DNA
Sammanfattning : This thesis concerns the development and evaluation of computational methods for analysis of genetic data. A particular focus is on ancient DNA recovered from archaeological finds, the analysis of which has contributed to novel insights into human evolutionary and demographic history, while also introducing new challenges and the demand for specialized methods. LÄS MER
2. Two Optimization Problems in Genetics : Multi-dimensional QTL Analysis and Haplotype Inference
Sammanfattning : The existence of new technologies, implemented in efficient platforms and workflows has made massive genotyping available to all fields of biology and medicine. Genetic analyses are no longer dominated by experimental work in laboratories, but rather the interpretation of the resulting data. LÄS MER
3. Statistical Methods for Genome Wide Association Studies
Sammanfattning : This thesis focus on various statistical methods for analyzing Genome Wide Association data. The thesis include four papers, three of them considers the analysis of complex traits, and the last one a method for analyzing mendelian traits. LÄS MER
4. Improving methods for Genome Wide Analysis of Coeliac Disease
Sammanfattning : .... LÄS MER
5. A computational and statistical framework for cost-effective genotyping combining pooling and imputation
Sammanfattning : The information conveyed by genetic markers, such as single nucleotide polymorphisms (SNPs), has been widely used in biomedical research to study human diseases and is increasingly valued in agriculture for genomic selection purposes. Specific markers can be identified as a genetic signature that correlates with certain characteristics in a living organism, e. LÄS MER