Sökning: "Genomic Characterization"

Visar resultat 1 - 5 av 118 avhandlingar innehållade orden Genomic Characterization.

  1. 1. Molecular Characterization of Bladder Cancer Subtypes

    Författare :Pontus Eriksson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bladder Cancer; Urothelial Carcinoma; Molecular Subtypes; Genomic Characterization; Gene Expression;

    Sammanfattning : Bladder cancer is one of the most common malignancies world-wide, and in Sweden approximately 3000 cases are diagnosed annually. Even though bladder cancer is so common there is low public awareness of the disease, and it has historically been less studied compared to other common types of cancer. LÄS MER

  3. 2. Molecular Characterization of Genomic Amplifications in Pancreatic Cancer

    Författare :Markus Heidenblad; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; FISH; Clinical genetics; PCR; cDNA microarray; array-based CGH; expression profiling; genomic profiling; Pancreatic cancer; gene amplification; Klinisk genetik;

    Sammanfattning : Pancreatic cancer includes multiple histologic subtypes that show large differences in their clinical and biological characteristics. Despite this diversity, more than 85% of the neoplasms in the organ are malignant ductal adenocarcinomas, which are the focus of the present thesis. LÄS MER

  4. 3. Characterization of Male Breast Cancer : From Molecule to Clinical Outcome

    Författare :Cecilia Nilsson; Marie-Louise Fjällskog; Leif Bergkvist; Thomas Hatschek; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; male breast cancer; immunohistochemistry; prognostic; cyclins; gene expression; genomic profiling; Oncology; Onkologi; Oncology; Onkologi;

    Sammanfattning : The aim of this thesis was to investigate different aspects of male breast cancer (MBC), and to compare these with findings in female breast cancer (FBC). In paper I, a population–based study was performed to investigate possible differences in treatment and outcome between MBC and FBC patients. LÄS MER

  5. 4. Characterization of chromosome abnormalities

    Författare :Anna Lindstrand; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Inborn chromosome abnormalities are a frequent cause of mental retardation and birth defects. Apart from aberrations that are visible in the microscope, a number of submicroscopic alterations have recently been discovered, and all of these chromosome changes are in fact the result of DNA alterations at the molecular level. LÄS MER

  7. 5. Genomic characterization of ETV6/RUNX1-positive acute lymphoblastic leukemia

    Författare :Henrik Lilljebjörn; Avdelningen för klinisk genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SNP array; array CGH; ETV6 RUNX1-positive ALL; childhood ALL; exome sequencing;

    Sammanfattning : The t(12;21) translocation generates the ETV6/RUNX1 fusion gene, present in 25% of childhood acute lymphoblastic leukemia. This fusion gene is important for leukemia development but is not sufficient for leukemia to arise. LÄS MER