Sökning: "Genome wide associations study GWAS"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden Genome wide associations study GWAS.

  1. 1. Genetics of complex disease

    Författare :Viktor Henmyr; Molekylär cellbiologi; []
    Nyckelord :complex disease; allergic rhinitis; Chronic rhinosinusitis; genetics; associations; GWAS; resequencing;

    Sammanfattning : To find true genetic associations in complex diseases, such as allergic rhinitis and chronic rhinosinusitis, is a difficult task. Both are polygenetic diseases where it is believed that genetic variation in several genes make up their phenotypes. LÄS MER

  2. 2. Using systems genetics to explore the complexity of leaf shape variation in Populus tremula

    Författare :Barbara Terebieniec; Nathaniel Street; Chung-Jui Tsai; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Populus; Arabidopsis; systems biology; systems genetics; spatial transcriptomics ST ; single nucleotide polymorphism SNP ; Genome wide associations study GWAS ; expression GWAS eGWAS ; molekylärbiologi; Molecular Biology;

    Sammanfattning : Leaves are essential for sustaining humanity as they function as the energy and oxygen-producing organ of plants. Intensive research on physiological processes has contributed immensely to our understanding of the function of leaves. However, comparatively little is known about how leaf size and shape is determined. LÄS MER

  3. 3. Novel statistical methods for genome-wide association summary statistics

    Författare :Zheng Ning; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : A general objective of genetic studies is to understand the genetic basis of complex traits such as height, body mass index (BMI), disease endpoints, etc. Such researches have been facilitated due to the completion of the human genome project and developments of high-throughput technologies. LÄS MER

  4. 4. Genetic factors affecting pregnancy duration in humans

    Författare :Jonas Bacelis; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; genomics; GWAS; Mendelian randomization; causal inference; preterm birth; pregnancy; gestation; height; text mining;

    Sammanfattning : This thesis investigates the mechanisms behind human pregnancy duration. Too short gestation is a direct cause of perinatal, neonatal, and infant mortality. Deviation from normal pregnancy length is also associated with a child's morbidity, even in the adulthood. LÄS MER

  5. 5. Interplay between genetics and environment in obesity

    Författare :Dmitry Shungin; Paul W Franks; Eivind Hovig; Umeå universitet; []
    Nyckelord :obesity; GWAS; gene-environment interactions; waist-hip ratio; body mass index; periodontitis; Mendelian randomization; heterogeneity of variance;

    Sammanfattning : Background. Being one of the largest current global health problems, obesity is a result of interplay between genetic and environmental factors. LÄS MER