Sökning: "Genome Wide Association Studies"

Visar resultat 1 - 5 av 176 avhandlingar innehållade orden Genome Wide Association Studies.

1. 1. Statistical Methods for Genome Wide Association Studies

   Författare :Malin Östensson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Genome Wide Association Studies; gene-gene interactions; Genotype imputation; allele sharing; haplotype sharing; Single Nucleotide Polymorphism; Celiac Disease; haplotype sharing;

   Sammanfattning : This thesis focus on various statistical methods for analyzing Genome Wide Association data. The thesis include four papers, three of them considers the analysis of complex traits, and the last one a method for analyzing mendelian traits. LÄS MER

3. 2. Genetic linkage and association studies in celiac disease: discoveries from whole genome analysis

   Författare :Svetlana Adamovic; Göteborgs universitet; []
   Nyckelord :Celiac Disease; genome-wide scan; linkage; association; GWAS; complex disease; autoimmune; 5q31-33; HLA; IL2 IL21;

   Sammanfattning : Celiac Disease (CD) or Gluten Sensitive Enteropathy (GSE) is a life-long disorder. It is characterized by inflammation in the small intestine of genetically predisposed individuals caused by inappropriate immune response to gluten, a protein enriched in some of our common grains (wheat, rye and barley). LÄS MER

4. 3. Novel Bioinformatics Applications for Protein Allergology, Genome-Wide Association and Retrovirology Studies

   Författare :Álvaro Martínez Barrio; Erik Bongcam-Rudloff; Teresa K Attwood; Uppsala universitet; []
   Nyckelord :data integration; web services; protein allergology; risk assessment; cross reactivity; endogenous retroviruses; ERV; dog; canine; GWAS; genome-wide association studies;

   Sammanfattning : Recently, the pace of growth in the amount of data sources within Life Sciences has increased exponentially until pose a difficult problem to efficiently manage their integration. The data avalanche we are experiencing may be significant for a turning point in science, with a change of orientation from proprietary to publicly available data and a concomitant acceptance of studies based on the latter. LÄS MER

5. 4. Genetics of pain : studies of migraine and pain insensitivity

   Författare :Anna Norberg; Monica Holmberg; Arn van den Maagdenberg; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Migraine; pain insensitivity; susceptibility genes; genome-wide scan; linkage; polymorphism; association; HSAN V; nerve growth factor; neurite outgrowth; Medical genetics; Medicinsk genetik;

   Sammanfattning : Pain is a major public health issue throughout the world. Increased understanding of the different forms of pain and identification of susceptibility genes could contribute to improved treatments. LÄS MER

7. 5. Genetic studies of stroke in Northern Sweden

   Författare :Sofie Nilsson Ardnor; Dan Holmberg; Jan Hillert; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stroke; linkage; genome wide scan; susceptibility loci; association; candidade gene; PDE4D; PIK3R1; extended pedigree; Medical genetics; Medicinsk genetik;

   Sammanfattning : Stroke is a common disorder of later life with a complex etiology, including both environmental and genetic risk factors. The inherited predisposition is challenging to study due to the complexity of the stroke phenotype. LÄS MER