Sökning: "Genetiska förändringar"
Visar resultat 1 - 5 av 102 avhandlingar innehållade orden Genetiska förändringar.
1. Genomic Profiling, Mutations and Deranged Signaling in Esophageal Cancer and Hereditary Colorectal Cancer
Sammanfattning : Esophageal cancer and colorectal cancer represents two major types of gastrointestinal tumors. Though refined surgery and introduction of novel chemotherapeutics have improved outcome, more than 2500 Swedes die from these diseases every year. Novel markers for early diagnosis, prognosis and treatment prediction are therefore needed. LÄS MER
2. Molecular Genetic Characterization of Acute Lymphoblastic Leukemia with a Poor Prognosis
Sammanfattning : Acute lymphoblastic leukemia (ALL) affects individuals at all ages, with peak incidences in children 50 years. ALL is broadly categorized into B-cell precursor (BCP) and T-cell ALL with specific clinical features associated with outcome. LÄS MER
3. IKAROS and LEUKEMIA
Sammanfattning : Acute lymphoblastic leukemia (ALL) is characterized by an accumulation of immature lymphoid cells in the bone marrow and is the most common cancer type in children. It is an immunophenotypically, morphologically, clinically, and genetically heterogeneous disorder that comprises several distinct subtypes. LÄS MER
4. Gene Expression Studies of Hematologic Malignacies
Sammanfattning : The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are characteristic of their primary genetic changes. LÄS MER
5. Behavioural differences and genetic relationships between four captive populations of red junglefowl (Gallus gallus) : possible implications for conservation
Sammanfattning : Conservation of species is to a large extent carried out by zoos where animals are kept in small populations under protected conditions. The ultimate goal of such ex situ conservation programs is to eventually reintroduce the animals into natural habitats to provide support for the survival of the species. LÄS MER