Sökning: "Genetic predisposition"

Visar resultat 16 - 20 av 160 avhandlingar innehållade orden Genetic predisposition.

  1. 16. Evaluation of genetic cancer predisposition and potential cancer genes

    Författare :Yaxuan Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Germline pathogenic TP53 variants are associated with a broad spectrum of hereditary cancers characterized from Li-Fraumeni syndrome (LFS) to hereditary breast cancer (HBC) outcomes, known as heritable TP53-related cancer (hTP53rc) syndrome. LFS is a rare inherited cancer syndrome characterized by premenopausal breast cancer, soft tissue sarcoma, brain tumor, osteosarcoma, and adrenocortical carcinoma. LÄS MER

  3. 17. Breast cancer in young women. Aspects of heredity and contralateral disease

    Författare :Annelie Augustinsson; LUCC: Lunds universitets cancercentrum; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Early-onset; Genetic counseling; Genetic testing; BRCA1 and BRCA2; Contralateral breast cancer; Breast cancer; Early-onset; Genetic counseling; Genetic testing; BRCA1 and BRCA2; Contralateral breast cancer;

    Sammanfattning : Breast cancer is the most commonly diagnosed cancer among women in Sweden, as well as worldwide. In Sweden, 8,288 women were diagnosed with invasive breast cancer in 2019, out of whom approximately 1.5% were younger than 35 years of age. LÄS MER

  4. 18. Overweight and obesity in the young and old: Prevalence, prevention and eating behavior

    Författare :Gabriele Eiben; Göteborgs universitet; []
    Nyckelord :prevention; BMI; elderly; young adults; lifestyle; diet; intervention; secular trends; twin study; EDI-2; genetic; environment;

    Sammanfattning : ABSTRACT Background: During the last 25 years the prevalence of overweight and obe-sity has increased dramatically, both in developed and developing countries. The World Health Organization is declaring it an epidemic. In Sweden the increase was almost 50% between 1980 and 2005. The largest increases oc-curred in the 16-24-year age group. LÄS MER

  5. 19. Genetic studies of colorectal cancer

    Författare :Johanna Skoglund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :colorectal cancer; linkage analysis; TGFBR1; case-control study; meta-analysis;

    Sammanfattning : Colorectal cancer is the third most commonly diagnosed cancer worldwide with an incidence rate of over 1 million cases per year. A genetic contribution has been suggested to be involved in around 35% of all colorectal cancer cases. LÄS MER

  7. 20. Functional analysis of genetic risk markers

    Författare :Jesper Robert Gådin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Regulatory variants are the main factors responsible for genetic predisposition to how e.g. humans react differently to the environment. LÄS MER