Avancerad sökning

Visar resultat 1 - 5 av 127 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. The matter of white matter in Alzheimer's disease. -On white matter disease from neuropathology and neuroimaging to clinical presentation

    Författare :Martin Sjöbeck; Lund Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; patologisk anatomi; Patologi allmän ; pathological anatomy; General pathology; medicinsk instrumentering; tomografi; radiologi; Klinisk fysiologi; medical instrumentation; tomography; radiology; executive dysfunction; Clinical physics; magnetic resonance imaging; diffusion tensor imaging; neuropathology; microvascular pathology; astrocytes; myelin; oligodendrocytes; white matter disease; Alzheimer s disease; neuropsychology; neuropsykologi; Neurologi; neurophysiology; neurofysiologi; Psychiatry; clinical psychology; psychosomatics; Psykiatri; klinisk psykologi; psykosomatik; Neurology;

    Sammanfattning : Alzheimer's disease (AD) is the most prevalent type of dementing disorder. The cortical pathology of AD has been recognized for almost a century. In later years, an associated pathological feature of AD has been identified which affects the white matter. LÄS MER

  3. 2. Two Types of Fibrils in ATTR Amyloidosis : Implications for Clinical Phenotype and Treatment Outcome

    Författare :Elisabet Ihse; Per Westermark; Per Hammarström; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amyloid; transthyretin; familial amyloidotic polyneuropathy; TTRV30M; non-TTRV30M; wild-type; liver transplantation; cardiomyopathy; fibril composition; Biokemi; Biochemistry; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Experimentell patologi; Experimental Pathology; Medical Biochemistry; Medicinsk biokemi; Molecular Biology; Molekylärbiologi; Pathology; Patologi;

    Sammanfattning : Systemic amyloidoses are a group of lethal diseases where proteins aggregate into fibrillar structures, called amyloid fibrils, that deposits throughout the body. Transthyretin (TTR) causes one type of amyloidosis, in which the aggregates mainly infiltrate nervous and cardiac tissue. LÄS MER

  4. 3. Electron Microscopy in Diagnostic Pathology with Reference to Mesenchymal Tumors

    Författare :Birgitta Carlén; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; synovial sarcoma; Kaposi´s sarcoma; epithelioid sarcoma; parachordoma; alveolar soft part sarcoma; small cell malignant tumors of childhood and adolescence; cultured cells; surgical specimens; Transmission electron microscopy; fine needle aspiration; General pathology; pathological anatomy; Patologi allmän ; patologisk anatomi;

    Sammanfattning : The experience acquired over a period of 15 years of diagnostic electron microscopy of fine needle aspirates and surgical specimens constitutes the base for this thesis. Some of the tumors analyzed represent rare soft tissue tumors, and consequently not very often ultrastructurally described. LÄS MER

  5. 4. Observations on cerebral amyloid angiopathy and microvascular pathology in Alzheimer's disease and vascular dementia

    Författare :Mattias Haglund; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Patologi allmän ; pathological anatomy; General pathology; Vascular dementia; Alzheimer s disease; Cerebral infarction; Locus ceruleus; White matter; Microvasculature; Cerebrovascular disease; patologisk anatomi; Ischemia; Cerebral amyloid angiopathy;

    Sammanfattning : Dementia is a state of permanent loss of cognitive function, most commonly affecting the elderly. With a rapidly growing aged population, the spectrum of disorders that lead to dementia is exerting an ever-increasing toll on patients, families and society alike. The most common dementing disorders are Alzheimer's disease and vascular dementia. LÄS MER

  7. 5. Immunoglobulin A nephropathy and disease complications : register-based studies

    Författare :Simon Jarrick; Jonas Ludvigsson; Sigrid Lundberg; Adina Symreng; Colin C. Geddes; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunoglobulin A nephropathy; nephrology; validation studies; register studies; cohort studies; mortality; ischemic heart disease; pregnancy; preterm birth;

    Sammanfattning : Immunoglobulin A nephropathy (IgAN) is the commonest primary glomerular disease worldwide. A kidney biopsy is required for the diagnosis. IgA immune-complex depositions sets off a cascade leading to renal scarring, proteinuria and hypertension. LÄS MER