Sökning: "Gene"

Visar resultat 11 - 15 av 6023 avhandlingar innehållade ordet Gene.

1. 11. Gene technology at stake : Swedish governmental commissions on the border of science and politics

   Författare :Jenny Eklöf; Kjell Jonsson; Christer Nordlund; Susanne Lundin; Umeå universitet; []
   Nyckelord :HUMANIORA; HUMANITIES; Gene technology; biotechnology; recombinant DNA technology; bioethics; ethics; risk; GMO; embryo; transgenic organisms; boundary organization; boundary object; governmental commission; regulatory policy; Sweden; public; expertise; democracy; History of science and ideas; Idé- o lärdomshistoria;

   Sammanfattning : This thesis examines the Swedish political response to the challenges posed by gene technology, seen through the prism of governmental commissions. It discerns and analyses continuities and changes in the Swedish political conception of gene technology, over the course of two decades, 1980–2000. LÄS MER

3. 12. Preproenkephalin Gene and mRNA : Studies of Structure, Function, Cocaine Responses in an Animal Model, and Genetic Association with Human Opiate Addiction

   Författare :Karl Steven LaForge; Fred Nyberg; Peter S. Eriksson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biological research on drug dependence; Neuropeptides; Endogenous opioid system; Drug addiction; Heroin; Cocaine; Gene expression; Genetic association; Biologisk beroendeforskning; Biological research on drug dependence; Biologisk beroendeforskning;

   Sammanfattning : The endogenous opioid enkephalin neuropeptides are mediators of pain perception and have been implicated in human addictions. The preproenkephalin gene and its mRNA have also provided many examples of tissue- and species-specific variations in mRNA structure produced through a variety of transcriptional and post-transcriptional mechanisms. LÄS MER

4. 13. Gene therapy of neuroblastoma

   Författare :Yvonne Arvidsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuroblastoma; gene therapy; PNP; ASK1; MASH1; IL-12; GM-CSF; immunotherapy; apoptosis.;

   Sammanfattning : Aims: The survival of children with advanced stages of neuroblastoma has not improved significantly during recent years. Therefore additional treatments based on other modalities need to be developed. The objective of this thesis was to investigate the possibility to develop gene therapy of neuroblastoma. LÄS MER

5. 14. From GWAS to gene : Zebrafish as a model system for large-scale studies of obesity and comorbidities

   Författare :Eugenia Mazzaferro; Marcel den Hoed; Randall Peterson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; zebrafish; genetic screens; gene editing; CRISPR Cas9; obesity; Medicinsk genetik; Medical Genetics;

   Sammanfattning : Obesity increases the risk of developing comorbidities such as cardiovascular and metabolic diseases. However, not all obese individuals develop comorbidities, and those that do not are referred to as “metabolically healthy obesity” individuals. LÄS MER

7. 15. Probabilistic Modelling of Domain and Gene Evolution

   Författare :Sayyed Auwn Muhammad; Jens Lagergren; Bastien Boussau; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phylogenetics; Phylogenomics; Evolution; Domain Evolution; Gene tree; Domain tree; Bayesian Inference; Markov Chain Monte Carlo; Homology Inference; Gene families; C2H2 Zinc-Finger; Reelin Protein; Computer Science; Datalogi;

   Sammanfattning : Phylogenetic inference relies heavily on statistical models that have been extended and refined over the past years into complex hierarchical models to capture the intricacies of evolutionary processes. The wealth of information in the form of fully sequenced genomes has led to the development of methods that are used to reconstruct the gene and species evolutionary histories in greater and more accurate detail. LÄS MER