Sökning: "Gene variants"

Visar resultat 16 - 20 av 585 avhandlingar innehållade orden Gene variants.

1. 16. Statistical methods for detecting gene-gene and gene-environment interactions in genome-wide association studies

   Författare :Mattias Frånberg; Jens Lagergren; Bengt Sennblad; Anders Hamsten; Heather Cordell; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Datalogi; Computer Science;

   Sammanfattning : Despite considerable effort to elucidate the genetic architecture of multi-factorial traits and diseases, there remains a gap between the estimated heritability (e.g., from twin studies) and the heritability explained by discovered genetic variants. LÄS MER

3. 17. Reward-related genes and alcohol dependence

   Författare :Sara Landgren; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alcohol; dependence; reward; smoking; body weight; gene; polymorphism; nAChR; ghrelin; GHS-R1A;

   Sammanfattning : Introduction: The rewarding properties of alcohol are mediated by the brain reward systems, specifically by the cholinergic-dopaminergic reward link, involving both nicotinic acetylcholine receptors (nAChRs) as well as the ghrelin signalling system. The susceptibility for developing alcohol dependence is influenced by genetic factors. LÄS MER

4. 18. Underlying genetic mechanisms of hereditary dystrophies in retina and cornea

   Författare :Jonsson Frida; Irina Golovleva; Carlo Rivolta; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cornea; retina; gene; mutation detection; inherited diseases; genetik; Genetics;

   Sammanfattning : Inherited retinal and corneal dystrophies represent a group of disorders with great genetic heterogeneity. Over 250 genes are associated with retinal diseases and 16 genes are causative of corneal dystrophies. LÄS MER

5. 19. Inflammasome polymorphisms and the Inflammatory Response to Bacterial Infections

   Författare :Berhane Asfaw Idosa; Eva Särndahl; Anne Kelly; Bo Söderquist; Alexander Persson; Johan Bylund; Örebro universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bacteremia; Cytokines; Gene variants; Inflammasome; Inflammation; Innate immunity; Neutrophils; Meningitis; Neisseria meningitidis; Biomedicin; Biomedicine;

   Sammanfattning : NLRP3 inflammasome; a key component of the innate immune system, can be activated by a number of pathogens and other threats of the body. Activation of the NLRP3 inflammasome triggers caspase-1 mediated maturationof IL-1β and IL-18. LÄS MER

7. 20. Reproductive isolation at contact zones

   Författare :Samuel Perini; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; hybrid zone; gene flow; genetic variants; mating; local adaptation; marine species; speciation;

   Sammanfattning : Speciation is among the most important evolutionary processes that contribute to biodiversity. It involves the formation of new species that have become reproductively isolated through a process that is not linear and varies in time and space. LÄS MER