Sökning: "Gene overexpression"
Visar resultat 1 - 5 av 288 avhandlingar innehållade orden Gene overexpression.
1. Gene Expression Studies of Hematologic Malignacies
Sammanfattning : The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are characteristic of their primary genetic changes. LÄS MER
2. Biochemical and Physiological Characterization of Nonsymbiotic Plant Hemoglobins
Sammanfattning : Hemoglobins (Hb) are usually associated with blood in humans. However, these proteins are widely distributed among living organisms. In plants the most known group are the leghemoglobins. Still, other Hbs that not participate in symbiosis are also found. LÄS MER
3. Cellular Resilience and Fragility in Response to Environmental and Gene Expression Perturbations
Sammanfattning : Cells are constantly subjected to perturbations. Whether these are extracellular or intracellular, they can be detrimental to cellular fitness. The cell has evolved elaborate systems and mechanisms that allow it to remain functional in the face of disturbances. LÄS MER
4. Animal genomics – gene discovery and gene characterization
Sammanfattning : This thesis involves two projects. The aim in the first project was to identify genomic regions associated with spontaneous autoimmune thyroiditis (SAT), which is a hereditary autoimmune disease that affects the obese strain (OS) of chicken, an animal model for human Hashimoto’s thyroiditis (HT). LÄS MER
5. Myocardial gene therapy and gene expression in angina pectoris
Sammanfattning : Background: Angiogenesis does not fully counteract myocardial ischemia in stable angina pectoris. Refractory angina pectoris, with remaining symptoms despite medication and no possibility for bypass surgery or angioplasty, is rather common. Angiogenic gene therapy is a novel treatment strategy for these patients. LÄS MER