Sökning: "Gene order rearrangements"

Visar resultat 1 - 5 av 27 avhandlingar innehållade orden Gene order rearrangements.

1. 1. Inferring evolution in bacteria using Markov chains and genomic signatures

   Författare :Daniel Dalevi; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Prediction suffix tree; Markov chains; Molecular evolution; Bioinformatics; Gene order rearrangements; Horizontal gene transfer; Variable length Markov chains;

   Sammanfattning : This thesis concerns the development of methods and models in evolutionary molecular biology. The techniques are also applicable to other similar biological problems. The first contribution is a novel classifier using fixed and variable length Markov chains that can discriminate between bacterial DNA of different species. LÄS MER

3. 2. Gene Mapping in Ficedula Flycatchers

   Författare :Niclas Backström; Hans Ellegren; Juha Merilä; Uppsala universitet; []
   Nyckelord :collared flycatcher; SNP; linkage disequilibrium; genetic map; pedigree;

   Sammanfattning : In order to get full understanding of how evolution proceeds in natural settings it is necessary to reveal the genetic basis of the phenotypic traits that play a role for individual fitness in different environments. There are a few possible approaches, most of which stem from traditional mapping efforts in domestic animals and other model species. LÄS MER

4. 3. Combinatorics of genome rearrangements and phylogeny

   Författare :Niklas Eriksen; KTH; []
   Nyckelord :;

   Sammanfattning : This thesis deals with combinatorial problems taken frombioinformatics. In particular, we study the problem ofinferring distances between bacterial species by looking attheir respective gene orders. We regard one of the gene ordersas a permutation of the other. LÄS MER

5. 4. Analysis of chromosomal rearrangements and gene copy number changes in breast cancer cells

   Författare :Pär Lundin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Genome changes in terms of numerical chromosomal aberrations and structural rearrangements, including deletions, amplifications and translocations, gradually accumulate in the genome during tumor development. These genomic changes are likely to play an important role in the process of tumor progression. LÄS MER

7. 5. Gene dose imbalances in children with mental retardation

   Författare :Jacqueline Schoumans; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Mental retardation; MCA MR syndromes; cromosome abnormalities; subtelomeric FISH; comparative genomichybridization; array-CGH;

   Sammanfattning : Submicroscopic chromosome aberrations can cause mental retardation (MR), congenital malformations and miscarriage. It is difficult to estimate the contribution of cytogenetic abnormalities to MR because of relatively low detection sensitivity of conventional cytogenetic methods used in the diagnostic setting. LÄS MER