Sökning: "Gene loss"

Visar resultat 1 - 5 av 735 avhandlingar innehållade orden Gene loss.

  1. 1. Probabilistic Modelling of Domain and Gene Evolution

    Författare :Sayyed Auwn Muhammad; Jens Lagergren; Bastien Boussau; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phylogenetics; Phylogenomics; Evolution; Domain Evolution; Gene tree; Domain tree; Bayesian Inference; Markov Chain Monte Carlo; Homology Inference; Gene families; C2H2 Zinc-Finger; Reelin Protein; Computer Science; Datalogi;

    Sammanfattning : Phylogenetic inference relies heavily on statistical models that have been extended and refined over the past years into complex hierarchical models to capture the intricacies of evolutionary processes. The wealth of information in the form of fully sequenced genomes has led to the development of methods that are used to reconstruct the gene and species evolutionary histories in greater and more accurate detail. LÄS MER

  3. 2. Retroviral gene transfer to repopulating hematopoietic cells

    Författare :Thomas Relander; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GLVR-1; VSV-G; amphotropic; GALV; long-term bone marrow culture; NOD SCID; retroviral vector; hematopoietic stem cells; stem cells; gene transfer; gene therapy; fibronectin; Clinical genetics; Klinisk genetik;

    Sammanfattning : Hematopoietic stem cells (HSCs) have the capacity to maintain hematopoiesis throughout life. HSCs are ideal targets for permanent gene transfer, as the transgene will be expressed in all the progeny of the gene-modified stem cells. LÄS MER

  4. 3. Targeting allelic loss in colorectal cancer

    Författare :Verónica Rendo; Tobias Sjöblom; Nickolas Papadopoulos; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer; gene editing; loss of heterozygosity; targeted therapy; whole genome sequencing;

    Sammanfattning : Targeted cancer therapy exploits molecular differences between tumor and normal cells to selectively kill cancer cells. Whereas targeting of activated oncogenes has proved clinically useful, few current therapies exploit loss-of-function mutations in tumor suppressor genes or in the genome at large. LÄS MER

  5. 4. Genetic studies of two inherited human phenotypes : Hearing loss and monoamine oxidase activity

    Författare :Jorune Balciuniene; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; linkage analysis; hearing loss; digenic inheritance; allelic association; monoamine oxidase; human genetic diversity; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : This thesis focuses on the identification of genetic factors underlying two inherited human phenotypes: hearing loss and monoamine oxidase activity. Non-syndromic hearing loss segregating in a Swedish family was tested for linkage to 13 previously reported candidate loci for hearing disabilities. LÄS MER

  7. 5. Nucleic acid in gene delivery and gene regulation

    Författare :Pedro Moreno; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The concept of gene therapy, initially attributed to a technology that would allow the correction of inherited genetic disease, has evolved over the years. The realization of the immense technical hurdles to achieve genetic correction led to a broadening of the concept now including the transfer of genetic material whose expression will counteract, mitigate or revert a disease phenotype. LÄS MER