Sökning: "Gene fusions"

Visar resultat 1 - 5 av 35 avhandlingar innehållade orden Gene fusions.

  1. 1. Comprehensive analysis of structural genomic alterations in cancer : Computational approaches for identifying cancer driver events

    Författare :Babak Alaei-Mahabadi; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Somatic structural variations; viral integrations; gene fusions; somatic genomic alterations;

    Sammanfattning : The transformation of a normal cell into a cancer cell involves the accumulation of somatic DNA alterations that confer growth and survival advantages. These genomic alterations can be different in terms of pattern and size, comprising single nucleotide variants (SNVs), small insertions or deletions (indels), structural variations (SVs) or foreign DNA insertions such as viral DNA. LÄS MER

  3. 2. Retargeting of adenovirus vectors. Viral ligands and cellular receptors

    Författare :Petra Henning; Göteborgs universitet; []
    Nyckelord :Adenovirus; vector; gene therapy; gene transfer; retargeting; detargeting; tumor targeting; fiber; pIX; affibody molecule; single chain antibody;

    Sammanfattning : Gene therapy is one of the newest technologies attempted to treat human cancer. Progress in the field has however been hampered by the lack of efficient and safe vectors. Ideal vectors should specifically transduce desired cells in vivo. This thesis is devoted to the development and evaluation of retargeted adenovirus type 5 (Ad5) vectors. LÄS MER

  4. 3. Pathogenetic Mechanisms in Soft Tissue Tumors

    Författare :Elsa Arbajian; Avdelningen för klinisk genetik; []
    Nyckelord :Soft tissue tumors; Sarcomas; Gene fusions; SNP array; Next generation sequencing; Haploidization; Point mutations;

    Sammanfattning : Soft tissue tumors (STT) constitute a heterogeneous group of tumors that arise in tissues of mesenchymal origin. They are currently classified according to morphology and resemblance to normal tissue into over 100 subtypes. LÄS MER

  5. 4. Role of Wnt5a in Prostate Cancer

    Författare :Azharuddin Sajid Syed Khaja; Malmö Urologisk cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate Cancer; Wnt5a; tissue micro array; Biochemical recurrence; Gene fusions;

    Sammanfattning : Wnt5a is a non-canonical secreted glycoprotein of the Wnt family that plays important roles in organ development and tissue orientation. Previous studies have reported that Wnt5a was upregulated at both mRNA and protein levels in prostate cancer, but information regarding its role in predicting clinical outcome in patients after radical prostatectomy is limited. LÄS MER

  7. 5. Studies of gene fusions and copy number alterations in salivary and adnexal neoplasms

    Författare :Marta Persson; Göteborgs universitet; []
    Nyckelord :cancer genetics; fusion oncogenes; chromosome translocation; MYB; NFIB; CRTC1; MAML2; salivary gland; breast; adenoid cystic carcinoma; mucoepidermoid carcinoma; hidradenoma;

    Sammanfattning : Cancer is a genetic disease caused by the accumulation of genetic changes such as mutations and chromosomal rearrangements. An increasing number of genetic studies of both hematological and solid neoplasms have shown that recurrent chromosome translocations often result in fusion oncogenes. LÄS MER