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1. 1. Contributions to Statistical Analysis of Gene Expression Data

   Författare :Anders Sjögren; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA microarray; differential expression; gene regulation; variance stabilising transformation; permutation; reference gene; housekeeping gene; bootstrap; quality control QC ; quality assurance QA ; quality assessment; empirical Bayes; weighted moderated t-statistic; WAME; DNA microarray;

   Sammanfattning : .... LÄS MER

3. 2. Statistical analysis of gene expression data

   Författare :Erik Kristiansson; Göteborgs universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; gene expression; DNA microarrays; linear models; empirical Bayes; quality control; gene regulation; categorical data analysis; logistic regression; heavy metal stress; ecotoxicology; gene expression;

   Sammanfattning : Microarray technology has become one of the most important tools for genome-wide mRNA measurements. The technique has been successfully applied to many areas in modern biology including cancer research, identification of drug targets, and categorization of genes involved in the cell cycle. LÄS MER

4. 3. Gene Expression Studies of Hematologic Malignacies

   Författare :Anna Andersson; Avdelningen för klinisk genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; cancer; onkologi; Cytologi; oncology; Cytology; acute myeloid leukemia; acute lymphoblastic leukemia; normal hematopoietic cells; cDNA microarray; gene expression profiling; hematopoiesis; pediatric leukemia; fusion gene; Pediatrics; Pediatri; Clinical genetics; Klinisk genetik; cancerology; Hematologi; extracellulära vätskor;

   Sammanfattning : The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are characteristic of their primary genetic changes. LÄS MER

5. 4. Avian Genome Evolution - Gene Expression, Gene Divergence and Sexual Dimorphism

   Författare :Sara Naurin; Biologiska institutionen; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; sex chromosome; avian genome evolution; gene expression; sexual dimorphism; Z chromosome;

   Sammanfattning : This study has focused on: (i) differences in how males and females use the genes in the genome, (ii) how sex chromosomes evolve and (iii) how the evolutionary rate of genes are affected by the chromosome on which they are located on and the gene expression level they experience. A large-scale microarray was developed for the zebra finch, Taeniopygia guttata and techniques were developed so that this microarray could also be used for wild passerine birds. LÄS MER

7. 5. Gene expression in carcinogenesis

   Författare :Heléne Fischer; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : It is important to understand the processes of carcinogenesis and to find out which genes are involved . One way to study the process on a molecular basis is to identify differences in gene expression. LÄS MER