Sökning: "Gene Prediction"

Visar resultat 1 - 5 av 184 avhandlingar innehållade orden Gene Prediction.

1. 1. Functional association networks for disease gene prediction

   Författare :Dimitri Guala; Erik L L Sonnhammer; Hjalmar Brismar; Yves Moreau; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; network biology; biological networks; network prediction; functional association; functional coupling; network integration; functional association networks; genome-wide association networks; gene networks; protein networks; fret; functional enrichment analysis; network cross-talk; pathway annotation; gene prioritisation; network-based gene prioritization; benchmarking; Biochemistry towards Bioinformatics; biokemi med inriktning mot bioinformatik;

   Sammanfattning : Mapping of the human genome has been instrumental in understanding diseasescaused by changes in single genes. However, disease mechanisms involvingmultiple genes have proven to be much more elusive. Their complexityemerges from interactions of intracellular molecules and makes them immuneto the traditional reductionist approach. LÄS MER

3. 2. Evolution of protein and non-coding RNA genes studied with comparative genomics

   Författare :Marcela Davila Lopez; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Bioinformatics; evolution; non-coding RNA; gene prediction; gene order; bidirectional promoter; homologue prediction; secondary structure; RNAse P; RNase MRP;

   Sammanfattning : The identification of protein and non-coding RNA (ncRNA) genes is one important step in the analysis of a genome. This thesis focuses on the identification and analysis of proteins and ncRNAs homologues by exploiting a variety of computational methods in order to reach conclusions as to their structure, function, evolution and regulation. LÄS MER

4. 3. Population-based prediction of atrial fibrillation

   Författare :Gustav Smith; Kardiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; atrial fibrillation; prediction; epidemiology; genetics; natriuretic peptide; heart failure;

   Sammanfattning : Background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and increases in prevalence. As AF confers increased risk of morbidity, stroke, dementia and mortality, a major objective of cardiovascular epidemiology today is the development of tools for prediction and prevention of AF and its consequences. LÄS MER

5. 4. Gene technology at stake : Swedish governmental commissions on the border of science and politics

   Författare :Jenny Eklöf; Kjell Jonsson; Christer Nordlund; Susanne Lundin; Umeå universitet; []
   Nyckelord :HUMANIORA; HUMANITIES; Gene technology; biotechnology; recombinant DNA technology; bioethics; ethics; risk; GMO; embryo; transgenic organisms; boundary organization; boundary object; governmental commission; regulatory policy; Sweden; public; expertise; democracy; History of science and ideas; Idé- o lärdomshistoria;

   Sammanfattning : This thesis examines the Swedish political response to the challenges posed by gene technology, seen through the prism of governmental commissions. It discerns and analyses continuities and changes in the Swedish political conception of gene technology, over the course of two decades, 1980–2000. LÄS MER

7. 5. A Study in RNA Bioinformatics : Identification, Prediction and Analysis

   Författare :Eva Freyhult; David Ardell; Robert Giegerich; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; RNA; bioinformatics; secondary structure; structure prediction; dynamic programming; energy landscape; homology search; sequence logo; tRNA; Bioinformatics; Bioinformatik;

   Sammanfattning : Research in the last few decades has revealed the great capacity of the RNA molecule. RNA, which previously was assumed to play a main role only as an intermediate in the translation of genes to proteins, is today known to play many important roles in the cell in addition to that as a messenger RNA and transfer RNA, including the ability to catalyze reactions and gene regulations at various levels. LÄS MER