Sökning: "Gal-1"

Hittade 4 avhandlingar innehållade ordet Gal-1.

  1. 1. Antibody-based immunotherapy of cancer From optimization to novel approaches

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Luuk van Hooren; Uppsala universitet.; [2018]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer immunotherapy; CD40; CTLA-4; PD-1; Gal-1; tertiary lymphoid structures;

    Sammanfattning : Antibody immunotherapy is a successful therapeutic approach to treat cancer. The overall aim of this thesis is to investigate the mechanisms of antibody-based immunotherapies and the role of the tumor microenvironment in mediating the anti-tumor immune response, in order to aid the development of improved immunotherapies for cancer patients. LÄS MER

  2. 2. Therapeutic Cancer Vaccines Targeting Molecules Associated with Tumor Angiogenesis

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Julia Femel; Uppsala universitet.; [2014]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tumor; therapeutic; cancer vaccine; angiogenesis; vasculature; fibronectin; galectin-1; Medical Cell Biology; Medicinsk cellbiologi; Oncology; Onkologi; Biomedicinsk laboratorievetenskap; Biomedical Laboratory Science; Medical Science; Medicinsk vetenskap;

    Sammanfattning : Induction of an endogenous antibody response by therapeutic vaccination could provide an alternative to cost-intensive monoclonal antibody-based treatments for cancer. Since the target of a cancer vaccine will most likely be a self-antigen, self-tolerance of the immune system must be circumvented. LÄS MER

  3. 3. UDP-sugar metabolizing pyrophosphorylases in plants formation of precursors for essential glycosylation-reactions

    Detta är en avhandling från Umeå : Umeå Universitet

    Författare :Daniel Decker; Umeå universitet.; [2017]
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chemical library screening; Cell wall synthesis; Glycosylation; Nucleotide sugars; Oligomerization; Protein structure; Reverse chemical genetics; Sugar activation; UDP-sugar synthesis; biokemisk farmakologi; biokemisk farmakologi; biokemi; Biochemistry; biology; biologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : UDP-sugar metabolizing pyrophosphorylases provide the primary mechanism for de novo synthesis of UDP-sugars, which can then be used for myriads of glycosyltranferase reactions, producing cell wall carbohydrates, sucrose, glycoproteins and glycolipids, as well as many other glycosylated compounds. The pyrophosphorylases can be divided into three families: UDP-Glc pyrophosphorylase (UGPase), UDP-sugar pyrophosphorylase (USPase) and UDP-N-acety lglucosamine pyrophosphorylase (UAGPase), which can be discriminated both by differences in accepted substrate range and amino acid sequences. LÄS MER

  4. 4. Characterization of Shigella dysenteriae type 1 hybrid vaccine candidates

    Detta är en avhandling från Stockholm : Karolinska Institutet, false

    Författare :Inger Fält; Karolinska Institutet.; Karolinska Institutet.; [1995]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Shigellae is endemic in many developing countries in the world and a major cause of childhooddiarrheal morbidity and mortality. Infections caused by Shigella dysenteriae type 1 areparticularly severe. LÄS MER