Sökning: "GWAS"

Visar resultat 21 - 25 av 108 avhandlingar innehållade ordet GWAS.

1. 21. Novel Bioinformatics Applications for Protein Allergology, Genome-Wide Association and Retrovirology Studies

   Författare :Álvaro Martínez Barrio; Erik Bongcam-Rudloff; Teresa K Attwood; Uppsala universitet; []
   Nyckelord :data integration; web services; protein allergology; risk assessment; cross reactivity; endogenous retroviruses; ERV; dog; canine; GWAS; genome-wide association studies;

   Sammanfattning : Recently, the pace of growth in the amount of data sources within Life Sciences has increased exponentially until pose a difficult problem to efficiently manage their integration. The data avalanche we are experiencing may be significant for a turning point in science, with a change of orientation from proprietary to publicly available data and a concomitant acceptance of studies based on the latter. LÄS MER

3. 22. The role of genetic variation and DNA methylation in human glucose metabolism and type 2 diabetes

   Författare :Tina Rönn; diabetes och endokrinologi Genomik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gene expression; oxidative phosphorylation; GWAS; SNP; DNA methylation; epigenetics; type 2 diabetes;

   Sammanfattning : The incidence of diabetes is increasing worldwide, with the most prevalent form being type 2 diabetes. Two fundamental processes contribute to the development of type 2 diabetes: insulin resistance in target organs and insufficient insulin secretion from the pancreatic beta-cells. LÄS MER

4. 23. Translational genetics identifies a novel target to treat fatty liver disease

   Författare :Kavitha Sasidharan; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fatty liver disease; human genetics; GWAS; PSD3; spheroids;

   Sammanfattning : Fatty liver disease (FLD) is rapidly prevailing as the most common liver disease worldwide, with an estimated of one-quarter of the global population affected. Environmental and genetic determinants contribute to FLD susceptibility. LÄS MER

5. 24. Conservation genomics in inbred Scandinavian wolves using bioinformatic methods

   Författare :Linnéa Smeds; Hans Ellegren; Giorgio Bertorelle; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; conservation genomics; Canis lupus; bioinformatics; Y chromosome; admixture; genetic load; structural variation; GWAS; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

   Sammanfattning : With the recent and unprecedented progress in retrieving DNA sequence information from a large number of individuals of any species, conservation genetic research has entered a new phase. Specifically, it has become possible to study how genomes of endangered species respond to reductions in population size. LÄS MER

7. 25. Mechanisms by which variants in the TCF7L2 gene increase the risk of developing Type 2 diabetes

   Författare :Yuedan Zhou; diabetes och endokrinologi Genomik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TCF7L2; rs7903146; Type 2 diabetes; β cell function; β cell survival; insulin secretion; proinsulin synthesis; proinsulin-to-insulin conversion; insulin maturation; open chromain; exon skipping; p53; TP53INP1; ISL1; MAFA; NEUROD1; PDX1; NKX6.1; PCSK1; PCSK2; SLC30A8; GWAS.;

   Sammanfattning : Type 2 diabetes mellitus (T2DM) is a heterogeneous disease with a multifactorial aetiology comprising of genetic and environmental factors. The common variant most highly associated with T2DM known to date is a SNP rs7903146 in the TCF7L2 gene. However, the role TCF7L2 plays in the development of T2DM was unclear. LÄS MER