Sökning: "GSTM1"

Visar resultat 6 - 10 av 19 avhandlingar innehållade ordet GSTM1.

  1. 6. Significance of polymorphisms in human xenobiotic metabolising enzymes

    Författare :Anna-Karin Alexandrie; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cigarette smoke is the primary cause of lung cancer but urban air pollution and certain occupational exposures have also been found to elevate the incidence of lung cancer. These exposures contain polycyclic aromatic hydrocarbons (PAH), which can be metabolically activated to highly reactive compounds capable of binding to DNA and initiating the carcinogenic process unless they are eliminated. LÄS MER

  3. 7. Genetic polymorphism of human drug metabolising enzymes : structural and functional studies

    Författare :Mikael Oscarson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : There is a pronounced interindividual variability in the levels and activity of many drug metabolising enzymes, which might cause differences in the sensitivity to and the toxicity of many clinically used drugs as well as environmental compounds such as nicotine and precarcinogens. In the present investigation the molecular genetic basis for some of the differences in the CYP2A6, CYP2D6, CYP2E1 and GSTM1 enzymes have been elucidated. LÄS MER

  4. 8. Exposure, health effects, immunological markers and biomarkers of susceptibility among Swedish rubber workers

    Författare :Lena S Jönsson; Avdelningen för arbets- och miljömedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Yrkesmedicin; arbetsmiljömedicin; industrial medicine; Public health; epidemiology; Folkhälsa; epidemiologi; Occupational health; Andningsorganen; rubber industry; polymorphisms; vulcanisation fumes; Respiratory system; nausea; headache; exposure-response relationships; biomarkers; symptoms; airways; eyes; TTCA; PAH; 1-hydroxypyrene;

    Sammanfattning : Workers in the rubber industry have an increased risk of several diseases, such as airway disease, cancer and probably cardiovascular disease. The exposure is very complex; carbon disulfide (CS2) and polycyclic aromatic hydrocarbons (PAHs) being two of the contaminants. LÄS MER

  5. 9. Interindividual differences in xenobiotic-metabolising enzymes : the human genetic factor

    Författare :Roman A McLellan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The vast number of human xenobiotic-metabolising enzymes display interindividual variability that can alter the disposition of any compound metabolised by these enzymes, including environmental chemicals and many clinically used drugs. Both genetic and non-genetic factors affect the levels and activities of these enzymes. LÄS MER

  7. 10. Carcinogenic polycyclic aromatic hydrocarbons : role of human glutathione transferases in conjugate formation and DNA protection

    Författare :Kathrin Sundberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Polycyclic aromatic hydrocarbons (PAHs) are widespread mutagenic and carcinogenic environmental pollutants, which requires metabolic activation to electrophilic intermediates and subsequent covalent binding to critical targets in DNA to elicit their biological activity. Bay- and fjord region diol epoxides (DEs) have been identified as the ultimate mutagenic and carcinogenic metabolites of PAHs. LÄS MER