Sökning: "GSTM1"

Visar resultat 16 - 19 av 19 avhandlingar innehållade ordet GSTM1.

  1. 16. DNA adducts formed by ethene and butadiene : quantitative analysis in rats and humans

    Författare :Chunyan Zhao; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :DNA adducts; 32P-postlabelling; cancer; genotoxicity; ethene; ethylene oxide; 1; 3-butadiene; epoxybutanediol;

    Sammanfattning : The present study has focused on DNA adduct formation by two important industrial and environmental chemicals, ethene and butadiene, in rats and humans. Ethene and butadiene are among the 50 chemicals produced in greatest volume in the United States. LÄS MER

  3. 17. Carcinogenic polycyclic aromatic hydrocarbons : theoretical, molecular, in vitro and cellular characterization of biotransformation and DNA damage

    Författare :Kristian Dreij; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Polycyclic aromatic hydrocarbons (PAHs) are widespread mutagenic and carcinogenic environmental pollutants, which require metabolic activation to electrophilic intermediates and subsequent covalent binding to critical targets in DNA to elicit their biological activity. Bayand fjord-region diol epoxides (DEs) have been identified as the ultimate mutagenic and carcinogenic metabolites of PAHs. LÄS MER

  4. 18. Influence of genetic polymorphisms on DNA repair, p53 mutations and cancer risk

    Författare :Charlotta Ryk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :polymorphisms; metabolism; DNA repair; p53; lung cancer; bladder cancer;

    Sammanfattning : Individuals have different susceptibility towards environmental exposures that may cause or contribute to disease. This inter-individual variation is partly due to genetic polymorphisms in genes involved in DNA repair and metabolism, which have potential to modulate the function of the encoded proteins. LÄS MER

  5. 19. Risk indicators for esophageal cancer : some medical conditions and tobacco-related indicators

    Författare :Kazem Zendehdel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Because of little progress in the prognosis and survival of esophageal cancer patients, the early diagnosis and prevention have been prioritized. Alcohol consumption and tobacco smoking are the main risk factors of squamous cell carcinoma, and high body mass index and gastroesophageal reflux are strongly linked to adenocarcinoma of the esophagus. LÄS MER