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Visar resultat 1 - 5 av 19 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Molecular Genetic Studies of Genes Predisposing for Glaucoma

    Författare :Mattias Jansson; Claes Wadelius; Annika Lindblom; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; glaucoma; MYOC; OCLM; GSTM1; OPTN; mutation analysis; Genetik; Clinical genetics; Klinisk genetik;

    Sammanfattning : Glaucoma is one of the leading causes of visual impairment in the world. In glaucoma, the patient’s peripheral vision is lost due to progressive and irreversible deterioration of the retinal ganglion cells and atrophy of the optic nerve. LÄS MER

  3. 2. Genetic polymorphisms, IGF-1, and oral contraceptive use in women from high-risk breast cancer families

    Författare :Maria Henningson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; familial breast cancer; premenopausal women; htSNP; GSTP1; polymorphism; BRCA1; BRCA2; IGF-1; oral contraceptives; CYP17; GSTT1; GSTM1;

    Sammanfattning : Breast cancer is the most common cancer among Swedish women, affecting more than 7000 women each year. About 5-10% of all breast cancers are hereditary, with a monogenic inheritance pattern, but only 2-4% are explained by germline mutations in BRCA1 or BRCA2. BRCA1/BRCA2 mutation carriers have a 60-80% risk of developing breast cancer. LÄS MER

  4. 3. Genetic polymorphisms in breast cancer in relation to risk and prognosis

    Författare :Erika Bågeman; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; age at diagnosis; breast cancer; polymorphism; CYP1A2; IGF1; GSTM1; CYP2C9; CYP2C8; coffee; GSTT1; ER; parity;

    Sammanfattning : Breast cancer is the most common cancer in women living in Sweden and the second most common cancer in the rest of the world. The risk of developing breast cancer is modified by environment, lifestyle, genetics and a combination of these factors. LÄS MER

  5. 4. Migraine in women : Epidemiological, clinical, genetic, and experimental aspects

    Författare :Peter Mattsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Migraine; aura; prevalence; age; CYP2D6; GSTM1; cold induced headache; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Sammanfattning : Migraine is a significant public-health problem. Few studies have focused on migraine inmiddle-aged and older women in the general population. LÄS MER

  7. 5. Environmental and genetic factors in lung cancer : epidemiologocal and biomolecular studies focusing on nonsmokers

    Författare :Fredrik Nyberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Lung cancer; case-control study; smoking misclassification; exposure misclassification; validation; bias; nonsmoker; smoking; environmental tobacco smoke; ETS; diet; biomarker; glutathione S transferase; GSTM1; N-acetyl transferase; NAT2; hypoxanthine-guanine phosphoribosiyl transferase; hprt; DNA; adducts;

    Sammanfattning : Tobacco smoking is the major cause of lung cancer. Other risk factors include exposure to environmental tobacco smoke (ETS), dietary habits and genetic factors. When studying such risk factors, confounding from smoking presents a pervasive methodological problem. LÄS MER