Sökning: "GSK3"
Visar resultat 1 - 5 av 7 avhandlingar innehållade ordet GSK3.
1. Mechanisms of Sensitization to Apoptosis in Multiple Myeloma
Sammanfattning : Multiple myeloma (MM) is a hematological tumor of plasma blast/plasma cell origin heterogeneous with respect to the morphological differentiation stage of the tumor cells, genetic alterations and course of disease. A challenge in MM research is to overcome resistance to therapy, which inevitably arises. LÄS MER
2. Annotating and making use of the Avena sativa cv. Sang reference genome
Sammanfattning : Oats is an important cereal used for both food and feed. The topic of this thesis is the annotation of the genome of oat (Avena sativa) cv. Sang, as well as some of the things this genome and its annotation have been used for. LÄS MER
3. Signaling to and from the sodium pump : effects of insulin and cardiotonic steroids
Sammanfattning : Insulin and proinsulin-connecting peptide (C-peptide) stimulate Na+,K+-ATPase activity. The molecular mechanism by which insulin and C-peptide regulate the Na-pump in differentiated primary human skeletal muscle cells (HSMCs) and primary human renal tubular cells (HRTCs) was determined. LÄS MER
4. Therapeutic myocardial angiogenesis and its pharmacological modulation
Sammanfattning : Angiogenesis is the formation of new blood vessels induced by the proliferation and migration of endothelial cells. Because angiogenesis is a complex process, therapeutic efficacy may be improved by overexpression of combined angiogenic factors. LÄS MER
5. Role of posttranslational modifications in regulation of Notch and transcriptional coactivator mastermind-like 1
Sammanfattning : The Notch signaling is an evolutionary conserved pathway enabling short range cell-cell interactions, crucial for diverse developmental and physiological processes during embryonic and adult life. The Mastermind-like (MAML) family of transcriptional coactivator proteins has been shown to play an essential role in regulation of Notch-mediated transcription. LÄS MER