Sökning: "GSK-3β"

Visar resultat 6 - 10 av 11 avhandlingar innehållade ordet GSK-3β.

  1. 6. Molecular Studies of Mast Cell Migration and Apoptosis : Two Ways of Regulating Mast Cell Numbers at Sites of Inflammation

    Författare :Jessica Alfredsson; Gunnar Nilsson; Hans-Uwe Simon; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pathology; mast cell; SCF; IL-3; FcεRI; migration; apoptosis; Bim; Bcl-2; Bcl-XL; Akt; FOXO; MAPK; Patologi; Pathology; Patologi;

    Sammanfattning : Upon activation mast cells release numerous proinflammatory mediators. With this feature, mast cells play an important role in host defense against pathogens, and are involved in tissue remodeling and wound healing. However, in cases of excessive inflammation the effects of mast cells are detrimental. LÄS MER

  3. 7. The role of Smad7 and TRAF6 in Prostate Cancer Cell Invasion, Migration and Survival

    Författare :Maria Ekman; Marene Landström; Carl-Henrik Heldin; Jonas Fuxe; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TGF-beta; cell migration; invasion; apoptosis; Smad7; APC; ATM; TRAF6; p53; PC3U; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Transforming growth factor (TGF) β is a tumor suppressor during early tumor development, by inhibiting proliferation and inducing apoptosis. At later stages of cancer, it becomes a tumor promoter, and promotes tumor cell migration and invasion. TGFβ signals via its type II and type I receptors to several downstream signaling pathways. LÄS MER

  4. 8. Mechanisms of therapy resistance in acute lymphoblastic leukemia

    Författare :Kinjal Shah; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALL; B-ALL; T-ALL; dexamethasone; FLT3; Signaling pathways; BCL2; resistance; PLK1; synergy;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is a highly aggressive pediatric cancer that can affect both B cells and T cells. The advent of new therapies has increased the cure rates for both B-ALL and T-ALL patients. However, some patients still experience relapse with a variable response to the treatment and display poor survival. LÄS MER

  5. 9. The role of androgen in prostate cancer cell invasion

    Författare :Yin-Choy Chuan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prostate cancer (PCa) is the most commonly diagnosed cancer in men in developed countries. Androgen deprivation therapy (ADT) is the mainstay treatment for patient diagnosed with PCa. However, the cancer will eventually relapse with metastatic cancer and become resistant to the treatment. LÄS MER

  7. 10. Intracellular signaling in human skeletal muscle following different modes of exercise

    Författare :Henrik Mascher; Eva Blomstrand; Jan Henriksson; Jørgen Jensen; Gymnastik- och idrottshögskolan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Medicin Teknik; Medicine Technology;

    Sammanfattning : Resistance and endurance exercise when performed regularly will cause specific adaptations in human skeletal muscle. Resistance exercise is known to increase strength and muscle mass while endurance training increases vascularisation and mitochondrial density which results in enhanced oxidative capacity. LÄS MER