Sökning: "GSK-3?"
Visar resultat 6 - 10 av 18 avhandlingar innehållade ordet GSK-3?.
6. The Regulation of Growth and Survival in Human Multiple Myeloma Cells by IGF-I Receptor Signaling
Sammanfattning : Multiple myeloma (MM) is an incurable B-cell malignancy mainly localized to the bone marrow. Our aim was to examine the growth- and survival-promoting role of the IGF-IR and its downstream signaling components in MM cells to identify potential targets for therapy. LÄS MER
7. Molecular Studies of Mast Cell Migration and Apoptosis : Two Ways of Regulating Mast Cell Numbers at Sites of Inflammation
Sammanfattning : Upon activation mast cells release numerous proinflammatory mediators. With this feature, mast cells play an important role in host defense against pathogens, and are involved in tissue remodeling and wound healing. However, in cases of excessive inflammation the effects of mast cells are detrimental. LÄS MER
8. The role of Smad7 and TRAF6 in Prostate Cancer Cell Invasion, Migration and Survival
Sammanfattning : Transforming growth factor (TGF) β is a tumor suppressor during early tumor development, by inhibiting proliferation and inducing apoptosis. At later stages of cancer, it becomes a tumor promoter, and promotes tumor cell migration and invasion. TGFβ signals via its type II and type I receptors to several downstream signaling pathways. LÄS MER
9. Transcriptional regulation of ribosomal RNA gene : actin, myosin and beyond
Sammanfattning : In the eukaryotic cell nucleus, actin and nuclear myosin 1c (NM1) are key regulators of RNA polymerase I (Pol I) transcription and function across the entire ribosomal RNA biogenesis pathway. At the gene level, actin interacts with Pol I and together with NM1 they have been suggested to facilitate assembly of Pol I at the gene promoter. LÄS MER
10. Role of NFAT (nuclear factor of activated T cells) in vascular smooth muscle
Sammanfattning : The calcium-dependent transcription factor NFAT was first described as a key player in immune cell regulation. Since then, NFAT signaling has been shown to be crucial for normal vascular development during embryogenesis. LÄS MER