Sökning: "GRPR interneurons"

Hittade 2 avhandlingar innehållade orden GRPR interneurons.

  1. 1. Functional Aspects of Peripheral and Spinal Cord Neurons Involved in Itch and Pain

    Författare :Bejan Aresh; Malin Lagerström; Klas Kullander; Martin Schmelz; Uppsala universitet; []
    Nyckelord :mGluR7; anaphylaxis; Grpr; Penk; Pdyn; Cre line; BAC cloning; spinal cord; transgenic line; Medicinsk vetenskap; Medical Science;

    Sammanfattning : We have investigated the role of the metabotropic glutamate receptor 7 (mGluR7) and the gastrin releasing peptide receptor (Grpr) population that are involved at different levels of itch transmission. We found that mGuR7 deficient mice displayed an anaphylaxis-like behavior when provoked with histamine. LÄS MER

  3. 2. Targeting and driving somatosensory neurons

    Författare :Fabio Freitag; Malin C. Lagerström; Andrew Todd; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pain; Itch; GRPR interneurons; dorsal horn; trigeminal nucleus caudalis; Barrel field;

    Sammanfattning : Pain and itch are two distinct sensations, but the fundamental question of how our nervous system distinguishes the processing and encoding of their related information is still far to be clearly delineated. At the spinal cord level, evidences have pointed out specific groups of neurons expressing the gastrin releasing peptide (Grp) and its receptor (Grpr) as responsible for carrying specifically itch-related information. LÄS MER