Sökning: "GRK2"
Hittade 4 avhandlingar innehållade ordet GRK2.
1. Pathophysiological importance of Beta1-Adrenergic receptor autoantibodies in the development of cardiomyopathy and heart failure. Clinically and experimentally
Sammanfattning : Idiopathic Dilated Cardiomyopathy (DCM) is a heart muscle disease of unknown originthat is characterized by ventricular dilation and the impaired contraction of the left orboth ventricles, resulting in progressive heart failure and sudden cardiac death. Antibodiesagainst different cardiac proteins have been found in DCM; they include antibodiesagainst the �1-adrenergic receptor (�1AR). LÄS MER
2. When the bear lost its tail : targeting the GRK/β-arrestins downstream IGF1R in non-epithelial malignancies
Sammanfattning : Plasma membrane receptors are highly specialized cell surface structures that receive extracellular information and process them into biological responses. Among them, this thesis focuses on two major receptor families: the G protein-coupled receptors (GPCR) and the receptor tyrosine kinases (RTKs). LÄS MER
3. β-adrenergic signalling and novel effects in skeletal muscle
Sammanfattning : Skeletal muscles have, due to their large mass, a big impact on the whole body metabolism. There are many signals that can regulate the functions of skeletal muscles and one such signal is activation of α- and β-adrenoceptors (α- and β-ARs) by epinephrine and norepinephrine. LÄS MER
4. Old receptors learn new tricks : biasing anti-IGF1R cancer therapy through the GPCR system
Sammanfattning : As cancers progress, tumor cells exploit the extracellular signals generated from plasma membrane receptors for cell growth, migration, and anti-apoptosis. G protein-coupled receptors (GPCR) and receptor tyrosine kinases (RTKs) are two important families of plasm membrane receptors, controlling multiple biological functions via their downstream signaling. LÄS MER
