Sökning: "GRK"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet GRK.

  1. 1. The materiality of serial practice : a microarchaeology of burial : (Materialitet i seriell praktik. En mikroarkeologisk gravanalys)

    Författare :Fredrik Fahlander; Göteborgs universitet; []
    Nyckelord :HUMANIORA; HUMANITIES; Microarchaeology; social theory; social practice; landscape; graves; Ajvide; Asea; Tegea; corporeality; Neolithic; GRK; Pitted Ware Culture.;

    Sammanfattning : The main concern of the thesis is the question of how to deal with matters of social heterogeneity in prehistory. A social reading of psychoanalytic theory of e.g. Jacques Lacan suggests that social heterogeneity generally is more likely than homogeneity in most social formations. LÄS MER

  3. 2. When the bear lost its tail : targeting the GRK/β-arrestins downstream IGF1R in non-epithelial malignancies

    Författare :Oana-Sonia Cismas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Plasma membrane receptors are highly specialized cell surface structures that receive extracellular information and process them into biological responses. Among them, this thesis focuses on two major receptor families: the G protein-coupled receptors (GPCR) and the receptor tyrosine kinases (RTKs). LÄS MER

  4. 3. Biased signalling at the IGF-1R : pitfalls and potential of the GRK/beta-arrestin system in cancer therapeutics

    Författare :Caitrin Crudden; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Embedded into the boundary between the living machinery and the external space, plasma membrane receptors allow cells to perceive their environment and elicit appropriate responses. Two of the largest classes of receptors are the G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs). LÄS MER

  5. 4. On neuroinflammation in psychotic disorders

    Författare :Carl Sellgren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuroinflammation has been implicated in several psychiatric conditions. Based on experimental studies, the glia-derived tryptophan metabolite kynurenic acid (KYNA) may be especially relevant for positive psychotic symptoms and impaired executive functioning. LÄS MER

  7. 5. Old receptors learn new tricks : biasing anti-IGF1R cancer therapy through the GPCR system

    Författare :Dawei Song; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : As cancers progress, tumor cells exploit the extracellular signals generated from plasma membrane receptors for cell growth, migration, and anti-apoptosis. G protein-coupled receptors (GPCR) and receptor tyrosine kinases (RTKs) are two important families of plasm membrane receptors, controlling multiple biological functions via their downstream signaling. LÄS MER