Sökning: "GPIbalpha"

Hittade 1 avhandling innehållade ordet GPIbalpha.

  1. 1. Role of GPIbαlpha Clustering and N-linked Carbohydrates in the Clearance of Refrigerated Platelets

    Författare :Emma Josefsson; Göteborgs universitet; []
    Nyckelord :Platelets; GPIbalpha; alphaMbeta2; phagocytosis; refrigerated platelets;

    Sammanfattning : The thesis focuses on understanding the mechanisms by which: 1) the macrophage alphaM-subunit recognizes betaN-acetylglucosamine (betaGlcNAc) residues on the von Willebrand factor receptor complex ((GPIbalpha,beta/IX)2V or vWfR) on refrigerated platelets and 2) refrigeration changes vWfR to elicit recognition through alphaMbeta2. Until recently, the only well-established mechanisms affecting platelet survival were antibody-mediated platelet clearance, consumption of platelets by coagulation reactions, and loss due to massive bleeding. LÄS MER