Sökning: "GLUTag cells"

Hittade 4 avhandlingar innehållade orden GLUTag cells.

  1. 1. Expression of the glucose-6-phosphatase system in endocrine cells

    Författare :Bee-Hoon Goh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Glue os e- 6 -phphspatas e; G6PC; G6PT1; G6PC2; G6PC3; pancreatic islets; InR1G9 cells; GLUTag cells; glucagon producing a-cells; GLP-1 producing L-cells.;

    Sammanfattning : Glucose-6-phosphatase (G6pase) is a multi-component enzyme system, which regulates the catalysis of gluco se-6 -phosphate (G6P) to glucose and inorganic phosphate. This reaction constitutes the final steps of both gluconeogenesis and glycogenolysis, processes that are critical in the maintenance of glucose homeostasis. LÄS MER

  3. 2. The role of cocaine- and amphetamine-regulated transcript in endocrine cells

    Författare :Liliya Shcherbina; Neuroendokrin cellbiologi; []
    Nyckelord :Type 2 Diabetes; T2D; cocaine and amphetamine-regulated transcript; CART; beta-cell; K-cell; L-cell; insulin; GIP; GLP-1; incretin hormones;

    Sammanfattning : Type 2 diabetes (T2D) is a metabolic disease characterized by insufficient insulin secretion and insulin resistance. Disturbed beta-cell function is the final culprit that leads to the development of T2D. In addition, impaired incretin effect is likely a part of the pathogenesis of T2D. LÄS MER

  4. 3. Molecular regulation of hormone secretion, growth and apoptosis of GLP-1-producing cells

    Författare :Camilla Kappe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Type 2 diabetes (T2D) spreads like an epidemic in today’s society, and there is a great need for new and improved treatments. T2D is characterized by hyperglycemia, resulting from impaired insulin production and insulin resistance in peripheral tissues. LÄS MER

  5. 4. Jejunal control of glucose homeostasis in the human body

    Författare :Erik Elebring; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucose homeostasis; ketogenesis; jejunum;

    Sammanfattning : Background: The prevalence of obesity and type-2 diabetes mellitus (T2DM) have risen dramatically over the last decades, and are major threats to the human health. Obesity, and also T2DM, is treated with lifestyle modifications, medications or by bariatric surgery, with varying success. LÄS MER