Sökning: "GIRK"

Hittade 3 avhandlingar innehållade ordet GIRK.

1. 1. A Purkinje cell Timing Mechanism. On the Physical Basis of a Temporal Duration Memory

   Författare :Fredrik Johansson; Associativ inlärning; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cerebellum; Purkinje cell; Timing; Temporal; Memory; Eyeblink conditioning; mGluR7; Kir3; GIRK;

   Sammanfattning : The standard view of neural signaling is that a neuron can influence its target cell by exciting or inhibiting it. Learning is thought to involve strengthening or weakening synaptic connections. For most behaviors, the brain must learn to produce precisely timed activity patterns. LÄS MER

3. 2. Electrophysiology-based investigations of G protein-coupled receptor pharmacology

   Författare :Richard Ågren; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : G protein-coupled receptors (GPCRs) constitute targets for ~34% of approved drugs. The muscarinic acetylcholine M2 receptor (M2R) activates G protein-coupled receptor inward rectifying potassium (GIRK) channels in the central nervous system and heart. Membrane potential modulates agonist potency at several GPCRs. LÄS MER

4. 3. Voltage sensitivity of dopamine D2-like receptors

   Författare :Kristoffer Sahlholm; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : G protein coupled receptors (GPCRs) mediate a multitude of responses serving hormonal, neurotransmitter, and sensory functions. These receptors are important drug targets; in fact, about 27 % of prescribed drugs are GPCR ligands. LÄS MER