Sökning: "GH secretion"
Visar resultat 16 - 20 av 58 avhandlingar innehållade orden GH secretion.
16. Growth hormone and the heart in children
Sammanfattning : Background and Aims: The fact that growth hormone (GH) influences cardiovascular structure and function is well established through both human and animal studies. Despite being secreted in a pulsatile fashion, only the impact of peak GH concentrations on cardiac parameters has previously been reported, and the time-dependency of cardiovascular effects during GH treatment has not been detailed. LÄS MER
17. Long-acting insulin analogs in type 1 diabetes : effects on metabolic control, endogenous insulin production and the GH-IGF-axis
Sammanfattning : The treatment goal in type 1 diabetes is to achieve near-normal glycemia. Despite of the advancements of subcutaneous insulin therapy and glucose monitoring, metabolic control is not fully normalized and secondary endocrine disturbances in the growth-hormone (GH) - Insulin-like Growth Factor (IGF)-axis are important for the deterioration of metabolic control, particularly in children at puberty. LÄS MER
18. Regulation of insulin-like growth factor-II in human liver
Sammanfattning : Insulin-like growth factors-I and -II (IGF-I and -II) are mitogens in a number of cell types and also have insulin-like actions. IGF-II has an autocrine role in a variety of malignancies; and hypoglycemia is well documented in conditions associated with elevated IGF-II precursor forms in the circulation. LÄS MER
19. Growth hormone and PPARa in the regulation of lipoprotein metabolism
Sammanfattning : In humans, apolipoprotein B (apoB)-100 is produced in the liver and apoB-48 is formed in the intestine. In the rat, however, the two forms of apoB are produced in the liver, leading to the formation of VLDL consisting of either apoB-48 or apoB-100. LÄS MER
20. Ghrelin action on gastrointestinal functions and appetite in rat and man
Sammanfattning : To study the effect of ghrelin on the contractility of smooth muscle strips in vitro as well as the effects on fasting small bowel motility and acid secretion in vivo in rats and gastric emptying in rats and humans. To study the effect of peripherally administered ghrelin on plasma levels of glucose, insulin, glucagon, orexin A (OXA), somatostatin and gastrin in rats and ghrelin, cholecystokinin (CCK), glucagonlike peptide-1 (GLP-1), peptide YY (PYY) and motilin in humans. LÄS MER