Sökning: "GFR[alpha]"

Hittade 5 avhandlingar innehållade ordet GFR[alpha].

  1. 1. The GDNF-receptor GFR-alpha-1 : neural expression patterns and regulation in stroke

    Författare :Arezou Sarabi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :G DNF; GFR-alpha-1 Strok; . Ischemia; receptors; calcium-binding proteins; gamma- aminobutyric acid; glutamic acid decarboxylase; dopamine; Parkinson s disease;

    Sammanfattning : Background: Neurotrophic factors in the mammalian nervous system are important for development and survival of neurons and for maintenance and plasticity of synaptic connections. Additionally, they have been shown to prevent neurodegeneration after damage to the central nervous system (CNS). LÄS MER

  3. 2. Changes in sensory systems during aging : an experimental study in the rat

    Författare :Esbjörn Bergman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :aging; behavior; primary sensory neuron; dorsal root ganglion; mystacial pad; sensory nerve ending; axon dystrophy; neuropeptides; B4; RT97; CTB; neurotrophins; trk; p75NTR; GFR[alpha]; RET; protein; mRNA;

    Sammanfattning : Aging is associated with sensorimotor disturbances, including increased proprioceptive thresholds. The present study aimed to clarify the occurrence of structural and biochemical alterations in sensory systems of behaviorally characterized aged rats. LÄS MER

  4. 3. Trophic factors, neuroprotection and spinal cord repair

    Författare :Johan Widenfalk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :spinal cord injury; GDNF; GFRalpha; neurotrophin; VEGF; olfactory ensheathing glia; weight-drop injury; in situ hybridization;

    Sammanfattning : Background: There is no cure for paralysis. The only drug therapy presently in use, acute high-dose methylprednisolone, has only modest effects on outcome. There is therefore a great need for new therapies. LÄS MER

  5. 4. On the actions of neurotrophic factors on the chromaffin cells of the adrenal medulla

    Författare :Petter Förander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Neural crest; chromaffin cells; neurotrophic factors; NGF; NT-3; NT4; CNTF; GDNF; TGFß; FGF2; glucocorticoids; Intra oculartransplantation ; primary cultures; neurite outgrowth;

    Sammanfattning : Chromaffin cells producing adrenaline or noradrenaline are the predominant cell type in the adrenal medulla, but ganglion cells and Schwann cells are also present. All cells of the adrenal medulla are derived from the neural crest, which is a transient neuroectoderm-derived embryonic structure. LÄS MER

  7. 5. Spinal motoneurons and molecules related to neurotrophic function after axon injury

    Författare :Henrik Hammarberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :immunohistochemistry; in situ hybridization; spinal cord; motoneuron; axotomy; survival; regeneration; MHC 1; leukocyte; cell culture; mRNA expression;

    Sammanfattning : The capacity of motoneurons to survive and regenerate new axons after injuries such as axotomy depends on a great variety of parameters. After sciatic nerve transection (SNT) in adult rats and to some extent after a ventral funiculus lesion (VFL), many cells survive and regeneration is highly prioritized. LÄS MER