Sökning: "GDNF"

Visar resultat 16 - 20 av 67 avhandlingar innehållade ordet GDNF.

1. 16. GDNF family ligands and neural stem cells in Parkinson's disease

   Författare :Peter Åkerud; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Parkinson's disease (PD) is a very common neurodegenerative disorder, characterized by a progressive degeneration of mainly nigrostriatal and mesolimbic dopaminergic neurons leading to tremor, rigidity and hypokinesia, the classical symptoms of the disease. Degeneration of noradrenergic neurons of the locus coeruleus are also involved in the progression of the disease, causing dementia and depression. LÄS MER

3. 17. GDNF and its receptors : a structure-function analysis of the NCAM-GDNF-GFRalpha1 complex and an examination of potential receptor candidates

   Författare :Dan Sjöstrand; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Neurotrophic factors are small, secreted proteins that are important players in the development and maintenance of the nervous system. Their functions span from neuronal survival and migration to neurite outgrowth and axon guidance, and in some cases even programmed cell death. LÄS MER

4. 18. Control of neuronal survival, migration and outgrowth by GDNF and its receptors

   Författare :Maurice Perrinjaquet; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Glial cell line-derived neurotrophic factor (GDNF) is the prototypical member of a family of growth factors that are indispensable in nervous system development and maintenance. GDNF signals by binding to a multi-component receptor complex comprised of the ligand-binding subunit GFRα1 and the signaling subunit RET or NCAM. LÄS MER

5. 19. Expression and function of GDNF family ligands and receptors in the nervous system

   Författare :Åsa Mikaels; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The search for novel neurotrophic factors promoting dopamine uptake and the survival of central dopaminergic neurons led to the discovery of a novel neurotrophic factor termed glial cell-line derived neurotrophic factor (GDNF). GDNF, neurturin (NTN), artemin (ART) and persephin (PSP) belong to the GDNF family ligands, and are potent survival-promoting factors for subsets of central and peripheral neurons. LÄS MER

7. 20. Structure-function studies of GDNF and other members of the TGF-beta superfamily

   Författare :Susanna Eketjäll; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The glial cell line-derived neurotrophic factor (GDNF) family is a distant subclass of the TGF-beta superfamily. The GDNF family of ligands, consisting of GDNF, neurturin (NTN), artemin (ART) and persephin (PSP), are potent survival and differentiation factors for neurons in the central and peripheral nervous systems. LÄS MER