Sökning: "GDF5"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet GDF5.

  1. 1. The role of Nkx3.2 and Gdf5 during zebrafish skeletal development

    Författare :Laura Waldmann; Tatjana Haitina; Abigail Tucker; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nkx3.2; Gdf5; zebrafish; jaw joint; joints; axial skeleton; appendicular skeleton; fin; enhancer conservation; CRISPR Cas9; OPT;

    Sammanfattning : The vertebrate skeleton is composed of bony and cartilaginous structures that are developed under the control of numerous genetic networks. The transcription factor Nkx3. LÄS MER

  3. 2. Musculoskeletal Development in Jawed Vertebrates : Gene function, cis-regulation, and 3D phenotypes in zebrafish

    Författare :Jake Leyhr; Tatjana Haitina; Sophie Sanchez; Per Ahlberg; Chrissy Hammond; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Nkx3.2; Gdf5; Mkx; zebrafish; jaw joint; skeleton; fin development; cartilage; tendon; ligament; enhancer; CRISPR Cas9; mutant; microCT; synchrotron; Biology with specialization in Evolutionary Organismal Biology; Biologi med inriktning mot evolutionär organismbiologi;

    Sammanfattning : Vertebrate skeletons are an intricate framework of bony and cartilaginous structures that form through carefully orchestrated developmental processes, guided by interacting genetic pathways that regulate cellular differentiation, migration, and tissue morphogenesis. The specific timing and localisation of gene expression shapes the diverse array of skeletal elements, from the flexible cartilages of the embryonic stage to the hardened bones that provide structural support in adulthood, and the joints and connective tissues that articulate the musculoskeletal system. LÄS MER

  4. 3. On the role of signaling pathways in the pathogenesis of osteoarthritis

    Författare :Johan Stenberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoarthritis; Signalling pathways; proteomics; genomics; GDF5; Wnt;

    Sammanfattning : The problem with degenerating cartilage tissues is one of the major causes for disability worldwide. The aetiology of the cartilage degenerating disease osteoarthritis is elusive and considered to be multifactorial. The aim of the present thesis was to find new hypotheses regarding the aetiology of osteoarthritis with focus on signalling pathways. LÄS MER

  5. 4. Development and Characterisation of a Rat Model of Parkinson's Disease

    Författare :Matilde Negrini; Beteendevetenskapligt laboratorium; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Parkinson s disease PD ; behavior; gene therapy; rat model; dopamine; alpha-synuclein; AAV Adeno-Associated virus ; PFFs;

    Sammanfattning : Preclinical rodent models of Parkinson’s Disease (PD) based on alpha-synuclein (αSyn) present some of the pathological hallmarks of the human condition, such as the progressive loss of dopaminergic neurons in the substantia nigra (SN) and the development of behavioural deficits. However, numerous reports on these models highlighted the variable outcomes that might originate from them if not validated properly. LÄS MER

  7. 5. Intervertebral disc regeneration. Studies on stem cell niches and cell transplantation

    Författare :Helena Barreto Henriksson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intervertebral disc stem cells degenerative disc cell transplantation stem cell niches disc degeneration mesenchymal stem cells cell therapy;

    Sammanfattning : Abstract Intervertebral disc regeneration Studies on stem cell niches and cell transplantation Helena Barreto Henriksson Gothenburg 2010 Low back pain is a common condition in the Western world and disc degeneration (DD) is considered a major cause. DD is characterized by dysfunctional cells and decreased matrix production. LÄS MER