Sökning: "GAG"

Visar resultat 21 - 25 av 84 avhandlingar innehållade ordet GAG.

  1. 21. Studies of Glycosaminoglycan Interactions - Surface Immobilization Strategies and Biosensing Applications

    Författare :Noomi Altgärde; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; glycosaminoglycans; interaction studies; growth factor; QCM-D; virus glycoprotein; SPR; surface immobilization;

    Sammanfattning : Many important biological functions of glycosaminoglycans (GAGs) have been highlighted in research literature during recent years. GAGs often serve as function-bearing structural elements in the extracellular matrix (ECM), but are also constituents of the cell membrane. GAGs take part in various biological mechanisms, e.g. LÄS MER

  3. 22. Exploration of the active site of β4GalT7 – Synthesis of substrates and inhibitors

    Författare :Karin Thorsheim; Centrum för analys och syntes; []
    Nyckelord :Xylosides; β4GalT7; β-1; 4-galactosyltransferase 7; glycosaminoglycan; synthesis;

    Sammanfattning : β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the biosynthesis of proteoglycans (PGs) and glycosaminoglycan (GAG) chains, which are important macromolecules involved in many biological processes such as cell growth and cell signaling as well as in cancer pathobiology and viral and bacterial infections. Despite its pivotal role, much is still unknown regarding the specific structure of GAGs and how the structure affects its functions. LÄS MER

  4. 23. Functional and molecular aspects of the glomerular barrier

    Författare :Anna Björnson Granqvist; Göteborgs universitet; []
    Nyckelord :glomerular endothelium; glycocalyx; podocyte; proteoglycan; glycosaminoglycans; nephrotic syndrome;

    Sammanfattning : The kidneys are crucial for maintaining a normal salt-water balance in the body, which is a prerequisite for life. They do that by filtering 180 liters of plasma per day across the highly permselective glomerular barrier and reabsorbing 99 % of the filtrate. LÄS MER

  5. 24. Interactions between herpes simplex virus type 1 glycoprotein C and cell surface glycosaminoglycans

    Författare :Kristina Mårdberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Herpes simplex virus-1; glycoprotein C; virus receptor; glycosaminoglycans; heparan sulfate; chondroitin sulfate;

    Sammanfattning : The cell surface glycosaminoglycan (GAG) heparan sulfate (HS) serves as an initial receptor for herpes simplex virus type 1 (HSV-1) and virus attachment to the HS molecule is mediated by the envelope glycoprotein C (gC). In the first part of this thesis, we aimed to define the HS-binding domain of viral gC. LÄS MER

  7. 25. Development and application of strategies for the analysis of modification patterns in chondroitin and dermatan sulphate

    Författare :Fang Cheng; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; reumatologi; muskelsystem; Skelett; Glycosaminoglycan; Proteoglycan; Chondroitin sulphate; dermatan sulphate; Sequencing analysis; Modification pattern.; Skeleton; rheumatology locomotion; muscle system; Metabolism; Biokemi; metabolism;

    Sammanfattning : Chondroitin (CS) and dermatan sulphate (DS) are socalled glycosaminoglycans (GAG) that are covalently attached to various type of proteins forming a subgroup within the diverse proteoglycan (PG) family. The PGs studied in this thesis are mostly extracellularly located and include aggrecan, biglycan and decorin. LÄS MER