Sökning: "GABA transport"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden GABA transport.

  1. 1. GABA and human spermatozoa : characterization and regulation of GABA transport proteins

    Författare :Arthur Aanesen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :GABA; spermatozoa; GABA transport; acrosome reaction; sperm motility; progesterone; protein kinase C; GAT-1; GAT-2; GAT-3; BGT-1;

    Sammanfattning : The present project aimed at investigating the interaction between GABA and human spermatozoa under in vitro conditions. Our initial hypothesis was that human spermatozoa had specific binding proteins for GABA and that the binding of GABA to such binding sites could affect sperm function. LÄS MER

  3. 2. Zinc-enriched neurons in the spinal cord, cerebellum and peripheral sympathetic system

    Författare :Zhan-You Wang; Göteborgs universitet; []
    Nyckelord :autometallography; axonal transport; confocal laser scanning microscopy; immuno-electron microscopy; immunofluorescence; inhibitory neurons; sympathetic neurons; synaptic vesicles; zinc ions; zinc transporter;

    Sammanfattning : Zinc ions are abundant in the nervous system and are involved in many biological functions. Most zinc is tightly bound to macromolecules, whereas a small fraction of zinc exists in synaptic vesicles of the zinc-enriched (ZEN) neurons, and can be visualized using various histochemical techniques, including autometallography (AMG). LÄS MER

  4. 3. Factors affecting alcohol self-administration : learning, environmental and genetic influences on behaviour

    Författare :Christopher Pickering; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ethanol; operant self-administration; addiction; reward; learning; lever press response; context; environmental cue; novelty; stress; glutamate; GABA; noradrenaline; PCR; gene expression; functional genomics; prefrontal cortex; hippocampus; amygdala;

    Sammanfattning : Alcoholism is a serious problem for society and is a very difficult disease to treat clinically. Often, the addict has periods of abstinence from alcohol followed by relapse to drinking and this cycle of use/non-use can repeat over many years. LÄS MER

  5. 4. Overcoming Limitations of Iontronic Delivery Devices

    Författare :Maria Seitanidou; Magnus Berggren; Daniel T Simon; Christopher Bettinger; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Organic electronic devices are considered as one of the best candidates to replace conventional inorganic electronic devices due to their electronic conductive functionality, low-cost production techniques, the ability to tune their optical and electronic properties using organic chemistry, and their mechanical flexibility. Moreover, these systems are ideal for bioelectronic applications due to their softness, biocompatibility, and most importantly, their electronic and ionic transport. LÄS MER

  7. 5. Patch-clamp studies of the GABAA receptor using microfluidic methods

    Författare :Maria Millingen; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ion channel; microfluidics; GABAA receptor;

    Sammanfattning : Ion channels are membrane proteins that passively transport ions. When activated, conformational changes within the protein lead to opening of a channel pore, and the flow of ions causes a change in the membrane potential. This is the fundamental process behind the generation and transduction of nerve impulses. LÄS MER